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Nelarabine Produkt Beschreibung

Nelarabine Struktur
121032-29-9
CAS-Nr.
121032-29-9
Englisch Name:
Nelarabine
Synonyma:
MAY;506u;506U78;Arranon;NELARABIN;GW 506U78;NELARABINE;Nelzarabine;Nelzarabine [USAN];Nelarabine (506U78)
CBNumber:
CB01011878
Summenformel:
C11H15N5O5
Molgewicht:
297.27
MOL-Datei:
121032-29-9.mol

Nelarabine Eigenschaften

Schmelzpunkt:
209-217°
alpha 
D20 +55.9° (c = 0.27 in DMF)
Siedepunkt:
721.0±70.0 °C(Predicted)
Dichte
1.98±0.1 g/cm3(Predicted)
pka
13.07±0.70(Predicted)
CAS Datenbank
121032-29-9(CAS DataBase Reference)

Sicherheit

Nelarabine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Nelarabine is a new member of the purine nucleoside antimetabolite class of drugs. It was launched as an intravenous infusion for treating relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) after at least two prior chemotherapy regimens. Nelarabine is a pro-drug of 9-b-D-arabinofuranosylguanine (ara-G), a deoxyguanosine derivative with a high level of T-cell selective cytotoxicity. Although Ara-G has been known since the 1960s, it has not been used in clinical studies due to its poor solubility. Nelarabine is the O-methyl derivative of ara-G with approximately 10 times greater aqueous solubility. It is demethylated in vivo by adenosine deaminase to produce ara-G, which is subsequently converted to the active 5’-triphosphate, ara-GTP. Accumulation of ara-GTP in leukemic blasts allows for incorporation into DNA, leading to inhibition of DNA synthesis and cell death.

Originator

Glaxo Wellcome (US)

Verwenden

A chemotherapy drug used in the treatment of relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL).

Verwenden

antineoplastic

Definition

ChEBI: A purine nucleoside in which O-methylguanine is attached to arabinofuranose via a beta-N9-glycosidic bond. Inhibits DNA synthesis and causes cell death; a prodrug of 9-beta /stereo >-D-arabinofuranosylguanine (ara-G).

Trademarks

Arranon (SmithKline Beecham).

Nelarabine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Nelarabine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 168)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22631 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30053 58
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3223 58
Jinan Carbotang Biotech Co.,Ltd.
+86 15866703830
figo.gao@foxmail.com CHINA 951 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23978 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58
Nanjing Baifuli Technology Co., Ltd.
+86-15335185688
sales@unisyn.cn CHINA 332 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23048 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35438 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63728 58

121032-29-9()Verwandte Suche:


  • (2R,3R,4S,5R)-2-(2-aMino-6-Methoxy-9H-purin-9-yl)-5-(hydroxyMethyl)-tetrahydrofuran-3,4-diol
  • Nelarabine (Arranon)
  • 506u
  • 9-β-D-Arabinofuranosyl-6-Methoxy-9H-purin-2-aMine
  • Arranon
  • GW 506U78
  • MAY
  • (2R,3S,4S,5R)-2-(2-AMino-6-Methoxy-9H-purin-9-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol
  • 506U78
  • NELARABIN
  • 9H-Purin-2-aMine, 9-b-D-arabinofuranosyl-6-Methoxy-
  • (2R,3S,4R,5R)-2-(2-amino-6-methoxy-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • 2-amino-9-β-D-arabinofuranosyl-6-methoxy-9H-purine
  • Nelarabine (506U78)
  • NELARABINE
  • Nelzarabine [USAN]
  • Nelzarabine
  • 9beta-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine
  • 121032-29-9
  • 1201032-29-9
  • 121032-29-2
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
  • 5g,10g,25g,100g
  • ARRANON
  • Anti-cancer&immunity
  • API
  • Inhibitors
  • Bases & Related Reagents
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