CYNARIN
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- CAS-Nr.
- 19870-46-3
- Englisch Name:
- CYNARIN
- Synonyma:
- 19870-46-3 CYNARIN;1,3-Dicaffeoylquinic acid;Dicaffeoylquinic Acid, 1,5-;1,5-di-O-Caffeoylquinic acid;(1S,3R,4R,5R)-1,3-O-Dicaffeoylquinic acid;(1S,3R,4R,5R)-1,3-Bis[3-(3,4-dihydroxyphenyl)acryloyloxy]-4,5-dihydroxycyclohexanecarboxylic acid;(1S,3R,4R,5R)-1,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-4,5-dihydroxycyclohexane-1-carboxylicaci;(1S,3R,4R,5R)-1,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-4,5-dihydroxycyclohexane-1-carboxylic acid;Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-
- CBNumber:
- CB02457303
- Summenformel:
- C25H24O12
- Molgewicht:
- 516.45
- MOL-Datei:
- 19870-46-3.mol
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CYNARIN Eigenschaften
- Siedepunkt:
- 819.9±65.0 °C(Predicted)
- Dichte
- 1?+-.0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- Löslichkeit
- soluble5mg/mL, clear, colorless to light yellow
- pka
- 2.50±0.50(Predicted)
- Farbe
- white to off-white
- Stabilität:
- Hygroscopic
CYNARIN Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
1,5-Dicaffeoylquinic acid (1,5-DCQA) has been found in
A. montana and is an HIV-1 integrase inhibitor and free radical scavenger. 1,5-DCQA inhibits HIV-1 integrase 3'' end processing, end joining, and disintegration with IC
50 values of 0.35, 0.56, and 0.84 μg/ml, respectively. It also inhibits HIV-1 replication in MT-2 T lymphoblastoid cells with an ED
50value of 2 μg/ml. 1,5-DCQA (0.25-1 μM) reduces the level of free radicals released from human polymorphonuclear (PMN) cells stimulated by N-formyl-Met-Leu-Phe (fMLP; ) in a dose-dependent manner. It also dose-dependently increases cell survival and glutathione (GSH) levels and decreases reactive oxygen species (ROS) production and lactate dehydrogenase (LDH) release in an oxygen-glucose deprivation/reperfusion assay in rat cerebral astrocytes when used at concentrations ranging from 5 to 100 μM.
Verwenden
1,5-Dicaffeoylquinic Acid acts as an anti-hyperlipidemic agent. In addition, acts as a neuroprotective agent against amyloid-β toxicity in the treatement of Alzheimer’s.
CYNARIN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
CYNARIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 116)Lieferanten
19870-46-3()Verwandte Suche:
- 1,3-Dicaffeoylquinic acid
- (1S,3R,4R,5R)-1,3-Bis[3-(3,4-dihydroxyphenyl)acryloyloxy]-4,5-dihydroxycyclohexanecarboxylic acid
- Dicaffeoylquinic Acid, 1,5-
- (1S,3R,4R,5R)-1,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-4,5-dihydroxycyclohexane-1-carboxylic acid
- 1,5-di-O-Caffeoylquinic acid
- Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-
- (1S,3R,4R,5R)-1,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-4,5-dihydroxycyclohexane-1-carboxylicaci
- 19870-46-3 CYNARIN
- (1S,3R,4R,5R)-1,3-O-Dicaffeoylquinic acid
- 19870-46-3
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
