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CP 94253 hydrochloride

CP 94253 hydrochloride Struktur
845861-39-4
CAS-Nr.
845861-39-4
Englisch Name:
CP 94253 hydrochloride
Synonyma:
CP94253 hydrochloride, 10 mM in DMSO;CP 94253 dihydrochloride, 5-HT1B agonist;1H-Pyrrolo[3,2-b]pyridine, 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-,monohydrochloride;CP94253,CP94253 hydrochloride,Serotonin Receptor,inhibit,CP 94253,CP-94253,5-hydroxytryptamine Receptor,Inhibitor,5-HT Receptor
CBNumber:
CB03146275
Summenformel:
C15H20ClN3O
Molgewicht:
293.8
MOL-Datei:
845861-39-4.mol
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CP 94253 hydrochloride Eigenschaften

storage temp. 
Desiccate at RT
Löslichkeit
Soluble to 25 mM in water and to 100 mM in DMSO
Aggregatzustand
Powder
Farbe
Pale yellow
InChI
InChI=1S/C15H19N3O.ClH/c1-2-9-19-14-4-3-13-15(18-14)12(10-17-13)11-5-7-16-8-6-11;/h3-5,10,16-17H,2,6-9H2,1H3;1H
InChIKey
PIIOXKQIZCVXMD-UHFFFAOYSA-N
SMILES
O(C1=CC=C2NC=C(C3=CCNCC3)C2=N1)CCC.Cl

Sicherheit

CP 94253 hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

CP 94,253 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1B (Ki = 2 nM in a radioligand binding assay). It is selective for 5-HT1B over 5-HT1A, 5-HT1D, 5-HT1C, and 5-HT2 receptors (Kis = 89, 49, 860, and 1,600 nM, respectively). CP 94,253 (10 and 17 mg/kg) reduces aggressive behavior in a resident-intruder test in mice, as well as decreases alcohol-induced aggression in mice with an ED50 value of 3.8 mg/kg. It decreases the time mice spend immobile in the forced swim test by 43%, indicating antidepressant-like activity, when administered at a dose of 5 mg/kg. CP 94,253 (2.5 mg/kg) also increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats.

Verwenden

CP 94253 Hydrochloride is a potent and selective serotonin 5-HT1B receptor agonist with anticonvulsant activity.

CP 94253 hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

CP 94253 hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 41)Lieferanten
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Finetech Industry Limited 027-87465837 19945049750
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Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4768 55
  • 1H-Pyrrolo[3,2-b]pyridine, 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-,monohydrochloride
  • CP94253,CP94253 hydrochloride,Serotonin Receptor,inhibit,CP 94253,CP-94253,5-hydroxytryptamine Receptor,Inhibitor,5-HT Receptor
  • CP 94253 dihydrochloride, 5-HT1B agonist
  • CP94253 hydrochloride, 10 mM in DMSO
  • 845861-39-4
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