PCO371

PCO371 Struktur
1613373-33-3
CAS-Nr.
1613373-33-3
Englisch Name:
PCO371
Synonyma:
PCO371;CPD2050;PCO371,PCO 371,inhibit,Inhibitor,THR,PCO-371,Thyroid Hormone Receptor;1-[3,5-Dimethyl-4-[2-[[4-oxo-2-[4-(trifluoromethoxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-5,5-dimethylimidazolidine-2,4-dione;1-[3,5-Dimethyl-4-[2-[[4-oxo-2-[4-(trifluoromethoxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-5,5-dimethyl-2,4-imidazolidinedione;2,4-Imidazolidinedione, 1-[3,5-dimethyl-4-[2-[[4-oxo-2-[4-(trifluoromethoxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-5,5-dimethyl-
CBNumber:
CB03355936
Summenformel:
C29H32F3N5O6S
Molgewicht:
635.65
MOL-Datei:
1613373-33-3.mol

PCO371 Eigenschaften

Dichte
1.47±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
Löslichkeit
DMSO: 125 mg/mL (196.65 mM)
Aggregatzustand
Solid
pka
8.39±0.10(Predicted)
Farbe
White to off-white
InChIKey
LDZJFVOUPUFOHX-UHFFFAOYSA-N
SMILES
C1(=O)N(C2=CC(C)=C(CCS(N3CCC4(N=C(C5=CC=C(OC(F)(F)F)C=C5)NC4=O)CC3)(=O)=O)C(C)=C2)C(C)(C)C(=O)N1

Sicherheit

PCO371 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

PCO371 is a novel, orally active small molecule that acts as a full agonist of PTHR1. PCO371 does not affect the PTH type 2 receptor (PTHR2), and analysis using PTHR1-PTHR2 chimeric receptors indicated that Proline 415 of PTHR1 is critical for PCO371-mediated PTHR1 activation[1].

Verwenden

PCO371 is a non-peptide chemical parathyroid hormone receptor 1 (PTHR1) agonist that exhibits PTH-mimetic activity in vivo via oral administration. PTH1R is a class B1 G protein-coupled receptor (GPCR) and a major regulator of mineral ion homeostasis and bone metabolism. PTH1R responds to ligands for parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) and activates Gs, Gq and β-arrestins. Natural and modified forms of these ligands induce substantial anabolic bone formation and are used in the clinical treatment of osteoporosis. PCO371 is used in the treatment of patients with hypoparathyroidism.

PCO371 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


PCO371 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 43)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhan Jingkang en Biomedical Technology Co., Ltd
+8613720134139
orders@jknbiochem.com China 5225 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6313 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581
sales@chemhifuture.com China 3136 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8474 58
LEAPCHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 43348 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 13720134139 13720134139
orders@jknbiochem.com China 5607 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185
sales-cpd@caerulumpharma.com China 3466 58
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686
sales@rechemscience.com China 2990 58
Shenzhen SUNGENING Bio-Medical Co., Ltd. 0755-28967200 13631290199
wxf@sungening.com China 9592 60

  • PCO371
  • CPD2050
  • 2,4-Imidazolidinedione, 1-[3,5-dimethyl-4-[2-[[4-oxo-2-[4-(trifluoromethoxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-5,5-dimethyl-
  • 1-[3,5-Dimethyl-4-[2-[[4-oxo-2-[4-(trifluoromethoxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-5,5-dimethyl-2,4-imidazolidinedione
  • PCO371,PCO 371,inhibit,Inhibitor,THR,PCO-371,Thyroid Hormone Receptor
  • 1-[3,5-Dimethyl-4-[2-[[4-oxo-2-[4-(trifluoromethoxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-5,5-dimethylimidazolidine-2,4-dione
  • 1613373-33-3
  • C29H32F3N5O6S
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