L-THREO-DIHYDROSPHINGOSINE

15639-50-6

CAS-Nr.: 15639-50-6

Englisch Name:: L-THREO-DIHYDROSPHINGOSINE

Synonyma:: SAFINGOL;L-threo-dihydrospingosine;L-THREO-DIHYDROSPHINGOSINE;L-THREO-SPHINGANINE, C18 CHAIN;L-threo-dihydrosphingosine (d18:0);L-threo-Dihydrosphingosine (Safingol);Safingol - CAS 15639-50-6 - Calbiochem;1,3-Octadecanediol, 2-amino-, (2S,3S)-;L-THREO-DIHYDROSPHINGOSINE (D18:0);SAFINGOL

CBNumber:: CB1192274

Summenformel:: C18H39NO2

Molgewicht:: 301.51

MOL-Datei:: 15639-50-6.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 67

L-THREO-DIHYDROSPHINGOSINE Eigenschaften

Schmelzpunkt:: 126-128 °C

Siedepunkt:: 446.2±25.0 °C(Predicted)

Dichte: 0.927±0.06 g/cm3(Predicted)

Flammpunkt:: 110 °C

storage temp.: -20°C

Löslichkeit: ≤0.25mg/ml in ethanol

Aggregatzustand: White solid

pka: 12.57±0.45(Predicted)

Sicherheit

WGK Germany	3

L-THREO-DIHYDROSPHINGOSINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

L-threo-Dihydrosphingosine is a lyso-sphingolipid protein kinase C inhibitor. It suppresses the growth of human oral squamous cell carcinoma (SCC) cells.

Allgemeine Beschreibung

A cell-permeable and reversible lyso-sphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding domain of PKC. Inhibits enzymatic activity and ³H-phorbol dibutyrate binding of purified rat brain PKC (IC₅₀ = 37.5 μM and 31 μM, respectively). Inhibits human PKC_α, the major overexpressed isoenzyme in MCF-7 DOXR cells (IC₅₀ = 40 μM). Enhances the cytotoxic effect of the chemotherapeutic agent Mitomycin C (MMC; Cat. Nos. 47589 and 475820) in gastric cancer cells by promoting drug-induced apoptosis.

Biochem/physiol Actions

Sphingosine kinase inhibitor; protein kinase C alpha (PKCα) -specific inhibitor; Sphingosine analog; potentiates the effect of doxorubicin (DOX) in tumor-bearing animals.

L-THREO-DIHYDROSPHINGOSINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

L-THREO-DIHYDROSPHINGOSINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 67)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4428	55
Yichang Zhongyitai Trading Co., Ltd.	0717-6449896 13886658719	root@zhongyitai.com	China	1976	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Alfa Chemistry	1-516-6625404	support@alfa-chemistry.com	United States	9171	60

SAFINGOL
L-THREO-SPHINGANINE, C18 CHAIN
L-THREO-DIHYDROSPHINGOSINE
L-threo-dihydrospingosine
L-THREO-DIHYDROSPHINGOSINE (D18:0);SAFINGOL
L-threo-dihydrosphingosine (d18:0)
1,3-Octadecanediol, 2-amino-, (2S,3S)-
Safingol - CAS 15639-50-6 - Calbiochem
L-threo-Dihydrosphingosine (Safingol)
15639-50-6
Biochemicals and Reagents
BioChemical
Lipids
Sphingolipids
Sphinganines
Sphingoid bases