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N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide

N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide Struktur
864082-47-3
CAS-Nr.
864082-47-3
Englisch Name:
N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide
Synonyma:
CS-557;RHO-15;GSK 429286 A;RHO-15(GSK429286A);GSK429286A, 10 mM in DMSO;GSK429286A (DMSO solution);GSK 429286A;GSK-429286A;RHO-15;GSK429286A;GSK-429286A;GSK 429286A;GSK429286A, ROCK1 and ROCK2 inhibitor;N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)-phenyl)-1,4,5,6-tetrahydrop
CBNumber:
CB12484722
Summenformel:
C21H16F4N4O2
Molgewicht:
432.37
MOL-Datei:
864082-47-3.mol
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N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide Eigenschaften

Siedepunkt:
688.4±55.0 °C(Predicted)
Dichte
1.468
storage temp. 
Sealed in dry,2-8°C
Löslichkeit
DMSO: ≥10mg/mL
pka
12.10±0.40(Predicted)
Aggregatzustand
powder
Farbe
white to beige
InChIKey
OLIIUAHHAZEXEX-UHFFFAOYSA-N
SMILES
C1(C)NC(=O)CC(C2=CC=C(C(F)(F)F)C=C2)C=1C(NC1C(F)=CC2=C(C=1)C=NN2)=O
CAS Datenbank
864082-47-3
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T
R-Sätze: 25
S-Sätze: 45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

GSK 429286 is a selective Rho-kinase (ROCK) inhibitor.It is orally available and has been shown to dramatically reduce mean arterial pressure in spontaneously hypertensive rats.

N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 149)Lieferanten
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Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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linda@hubeijusheng.com CHINA 22963 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49975 58
career henan chemical co 		+86-0371-86658258 +8613203830695
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 marketing@targetmol.com United States 32435 58
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Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739
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Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471
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InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
  • RHO-15(GSK429286A)
  • GSK 429286 A
  • RHO-15
  • N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide
  • GSK 429286 A N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide
  • N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide GSK 429286 A
  • N-(6-Fluoro-1H-indazol-5-yl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-3-pyridinecarboxamide
  • N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide
  • N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)-phenyl)-1,4,5,6-tetrahydrop
  • N-(6-fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide
  • CS-557
  • GSK429286A;GSK-429286A;GSK 429286A
  • GSK 429286A;GSK-429286A;RHO-15
  • 3-Pyridinecarboxamide, N-(6-fluoro-1H-indazol-5-yl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-
  • N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide USP/EP/BP
  • GSK429286A (DMSO solution)
  • GSK429286A, ROCK1 and ROCK2 inhibitor
  • GSK429286A, 10 mM in DMSO
  • 864082-47-3
  • Inhibitors
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