PHENYL 2-(TRIMETHYLSILYL)ETHYL SULFONE Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
white fine crystalline powder
Physikalische Eigenschaften
mp 52 °C.
Verwenden
(2-Phenylsulfonylethyl)trimethylsilane is widely used as reagent for the synthesis of mono- and 1,1-disubstituted alkenes via sulfone metalation, alkylation, and fluoride-induced elimination.
A sequence involving metalation, alkylation, and fluoride-induced elimination of benzenesulfinate allows the conversion of (2) to a terminal alkene. An analogous sequence involving a double alkylation of (2) provides a 1,1-disubstituted alkene (eq 2). The lithio derivative of (2) has also been used to prepare cyclopropylidene derivatives, homoallylic alcohols, and allyl silanes via the Julia alkenation.
synthetische
(2-phenylsulfonylethyl)trimethylsilane
(2) is prepared by radical addition of thiophenol to
vinyltrimethylsilane to give (2-phenylthioethyl)trimethylsilane
(1), which is then oxidized with hydrogen peroxide).
läuterung methode
Dissolve it in Et2O, wash it with saturated HCO 3 followed by saturated NaCl, H2O and dried (MgSO4). Evaporation leaves residual crystals with m 52o. [Hsiao & Shechter Tetrahedron Lett 23 1963 1982, Bortolini et al. J Org Chem 53 2688 1985.]
PHENYL 2-(TRIMETHYLSILYL)ETHYL SULFONE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
