Dmt-2'fluoro-da(bz) amidite
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- CAS-Nr.
- 136834-22-5
- Englisch Name:
- Dmt-2'fluoro-da(bz) amidite
- Synonyma:
- 2’-F-dA(Bz) Amidite;2'-F-Bz-A Phosphoramidite;Bz-2'-F-dA Phosphoramidite;Dmt-2'fluoro-da(bz) amidite;Dmt-2'fluoro-da(bz) amidite;2'-F-N6-Bz-dA phosphoramidite;2'-F-Bz-dA-CE-Phosphoramidite;2'-F-dA(Bz)-CE Phosphoramidite;N6-Bz-5'-O-DMT-2'-fluoro-dA-CE;DMT-2'-F-dA(bz) Phosphoramidite
- CBNumber:
- CB13141318
- Summenformel:
- C47H51FN7O7P
- Molgewicht:
- 875.92
- MOL-Datei:
- 136834-22-5.mol
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Dmt-2'fluoro-da(bz) amidite Eigenschaften
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- Aggregatzustand
- Powder
- pka
- 7.87±0.43(Predicted)
- InChIKey
- ZDIBABNMVQPXHU-JWQXGDSTNA-N
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
Dmt-2'fluoro-da(bz) amidite Chemische Eigenschaften,Einsatz,Produktion Methoden
Synthese
3-((Bis(diisopropylamine)phosphanyl)oxy)propanenitrile (6.42 g, 21.3 mmol, 6.77 mL, 1.8 eq) was added to a solution of N-(9-((2R,3R,4R,5R)-5-((bis(4- methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-9H- purine-6-yl)benzamide (8.0 g, 11.8 mmol, 1.0 eq) in DCM (42 mL) at 0 °C followed by DCI (2.24 g, 18.9 mmol, 1.6 eq). The mixture was warmed to 25 °C and stirred for 3 hours. Two parallel reactions were carried out. The combined remedies were then diluted with DCM (150 mL), the organic layer was washed with sat NaHCO3 solution (200 mL) and brine (100 mL), dried over Na2SO4, filtered and concentrated, the crude was purified by column chromatography to give Dmt-2'fluoro-da(bz) amidite (18.0 g, 18.5 mmol, 78.1% yield, 90% purity) as a white solid.
Dmt-2'fluoro-da(bz) amidite Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Dmt-2'fluoro-da(bz) amidite Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 128)Lieferanten
- N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoroadenosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
- (2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- DMT-2'-F-dA(Bz)-CE Phosphoramidite
- 5'-Dimethoxytrityl-N-Benzoyl-2'-fluoro-3'-[(2-cyanoethyl)-(N,Ndiisopropyl)]-phosphoramidite-deoxyadenosine
- Bz-2'-F-dA Phosphoramidite
- (2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite, >97%
- N6-Benzoyl-5'-O-(4,4'-Dimethoxy trityl)-2'-deoxy-2'-fluoroadenosine-3'-O-[(2-cyanoethyl)-(N,N-diiso-propyl)]phosphoramidite
- 5'-DMT-2'-F-Bz-dA Phosphoramidite
- Dmt-2'fluoro-da(bz) amidite
- 2'-F-dA(Bz)-CE Phosphoramidite
- N6-Bz-5'-O-(4, 4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-CE-Phosphoramidite
- Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite
- 2'-F-N6-Bz-dA phosphoramidite
- 2'-DEOXY-2'-FLUORO-N6Bz-ADENOSINE-3'-CE-PHOSPHORAMIDITE
- 2'-fluoro-N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-CE-Phosphoramidite
- 5'-O-DMT-2'-Fluoro-N6-Benzoyl-2'-deoxyadenosine 3'-CE phosphoramidite
- 5'-O-DMT-2'-F-Benzoyl-Deoxyadenosine-CE Phosphoramidite
- DMT-2'-F-dA(bz) Phosphoramidite
- N6-Bz-5'-O-DMT-2'-fluoro-dA-CE
- 5'-O-DMT-2'-F-N6- Benzoyl-2'-Deoxy Adenosine -3’-Cyanoethyl Phosphoramidite
- 2'-Fluoro-N-Bz Adenosine Amidite
- N6-Benzoyl-5’-O-(4, 4’-dimethoxytrityl)-2’-fluoro-2’-deoxyadenosine-3’-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
- DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite
- 2’-F-dA(Bz) Amidite
- 5'-ODMT-2'-Fluoro-N-Bz Adenosine-3'-OCEPA
- Dmt-2'fluoro-da(bz) amidite
- 2'-F-Bz-A Phosphoramidite
- DMT-2'-F-dA(Bz)-CE Phosphoramidite
- 2'-F-Bz-dA-CE-Phosphoramidite
- 2'-fluoro-N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-CE-Phosphoramidite
- 136834-22-5
- Amidite
