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Palmidrol Produkt Beschreibung

Palmitoylethanolamide Struktur
544-31-0
CAS-Nr.
544-31-0
Bezeichnung:
Palmidrol
Englisch Name:
Palmitoylethanolamide
Synonyma:
AM 3112;Impulsin;Palmidrol;PEA PALMIDROL;Loramine P 256;PALMITAMIDE MEA;Mackpeart DR 14V;Cetylamide ethanol;PALMITOYLETHANOLIDE;PALMITYLETHANOLAMIDE
CBNumber:
CB1401035
Summenformel:
C18H37NO2
Molgewicht:
299.49
MOL-Datei:
544-31-0.mol

Palmidrol Eigenschaften

Schmelzpunkt:
97-98℃
Siedepunkt:
461.5±28.0 °C(Predicted)
Dichte
0.910±0.06 g/cm3(Predicted)
RTECS-Nr.
ML8950000
storage temp. 
-20°C
Aggregatzustand
White solid
pka
14.49±0.10(Predicted)
InChIKey
HXYVTAGFYLMHSO-UHFFFAOYSA-N
CAS Datenbank
544-31-0
EPA chemische Informationen
Palmitoylethanolamide (544-31-0)

Sicherheit

WGK Germany  2
TSCA  Yes

Palmidrol Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Palmitoylethanolamide (PEA) is a fatty acid amide produced in the body that binds to and activates the peroxisome proliferator-activated receptor alpha (PPAR-α). It was initially described as an agonist to the type 2 cannabinoid receptor (CB2), though it is now recognized that PEA does not bind to cannabinoid receptors. PEA is known to have anti-inflammatory, analgesic, and neuroprotective properties. PEA supplements have been used by people with chronic pain as well as those with neuropathic pain.

Chemische Eigenschaften

white powder

Verwenden

PEA consists of palmitic acid and ethanolamine. It is the hydrolyzed form of N-(2-hydroxyethyl)-palmitamide, a crystalline structure isolated in soy lecithin. It is this hydrolyzed substance that accounts for the anti-inflammatory properties that were first noted by scientists in 1957. PEA's effects on the immune system have been studied since 1939.
PEA can be synthesized within the human body from the abundant fatty acid palmitic acid, but it is not dependent or influenced by dietary consumption of fatty acids. Palmitic acid in the diet is derived from dairy products such as cheese and butter, palm tree oil, and animal meat products. However, increasing palmitic acid in the hope of increasing endogenous PEA synthesis will not be effective.
The anti-inflammatory properties of PEA are due to its ability to inhibit inflammation-causing proteins called cytokines. Cytokines are released during periods of inflammation. PEA can suppress the secretion of tumor necrosis factor alpha (TNF alpha), a cytokine, while also inhibiting the release of interleukins. Interleukins are a specific class of cytokines which belong in the immunological system and are activated during the process of inflammation.

Verwenden

Palmitoylethanolamide has been used as a reference standard in mass spectrometry (MS/MS).

Definition

ChEBI: An N-(long-chain-acyl)ethanolamine that is the ethanolamide of palmitic (hexadecanoic) acid.

Biologische Funktion

Palmitoylethanolamide (PEA) is a fatty acid amide molecule involved in a variety of cellular functions in chronic pain and inflammation. It has been shown to have neuroprotective, anti-inflammatory, anti-nociceptive (antipain) and anti-convulsant properties. Often in people with chronic disorders, the body does not produce enough PEA, which causes problems.
Taking PEA to supplement the body’s shortage is may be beneficial if you have chronic and neuropathic pain and inflammation, as has been demonstrated in clinical trials. These include peripheral neuropathies such as diabetic neuropathy, chemotherapy-induced peripheral neuropathy, carpal tunnel syndrome, sciatic pain, osteoarthritis, low-back pain, failed back surgery syndrome, dental pains, neuropathic pain in stroke and multiple sclerosis, chronic regional pain syndrome, chronic pelvic pain, postherpetic neuralgia, and vaginal pains.

Biologische Aktivität

Palmitoylethanolamide (PEA) is a natural fatty acid amide of ethanolamine and palmitic acid. It is found in soybeans, egg yolk, and many other food sources. PEA is an endogenous cannabinoid receptor agonist. It is a peroxisome proliferator-activated receptor α (PPAR-α) ligand. PEA possesses anti-inflammatory, anti-allergic, neuroprotective, and analgesic activities. It belongs to the class of lipid mediators and the N-acylethanolamine family. PEA blocks the release of pro-inflammatory mediators from activated mast cells and prevents the recruitment of activated mast cells at the site of nerve injury.

Biochem/physiol Actions

Palmitoylethanolamide (PEA) is a natural fatty acid amide of ethanolamine and palmitic acid. It is found in soybeans, egg yolk, and many other food sources. PEA is an endogenous cannabinoid receptor agonist. It is a peroxisome proliferator-activated receptor α (PPAR-α) ligand. PEA possesses anti-inflammatory, anti-allergic, neuroprotective, and analgesic activities. It belongs to the class of lipid mediators and the N-acylethanolamine family. PEA blocks the release of pro-inflammatory mediators from activated mast cells and prevents the recruitment of activated mast cells at the site of nerve injury.

Nebenwirkungen

There are no known problematic side-effects. PEA can be taken together with any other substance. It enhances the pain-relieving effect of classic analgesics and anti-inflammatories.
Palmitoylethanolamide can be used in combination with other substances without any side effects.

Palmidrol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Palmidrol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 187)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Pharmyao, All for life--- A Specific Trading Platform For Reference Standard Material
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020-81716319 sales@pharmyao.com CHINA 173 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 310 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 15418 58
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com China 9165 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD
+8619933070948
claire@hbyingong.com China 687 58
Zhejiang ZETian Fine Chemicals Co. LTD
18957127338
stella@zetchem.com China 2008 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2940 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
alice@crovellbio.com China 5941 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58

544-31-0(Palmidrol)Verwandte Suche:


  • N-(2-HYDROXYETHYL)HEXADECANAMIDE
  • N-HEXADECANOYLETHANOLAMINE
  • PEA PALMIDROL
  • PALMITYLETHANOLAMIDE
  • PALMITOYLETHANOLAMIDE
  • PALMITOYLETHANOLAMIDE N-(2-HYDROXYETHYL)HEXADECANAMIDE
  • n-(2-hydroxyethyl)-hexadecanamid
  • Palmidrol
  • PALMITAMIDE MEA
  • Impulsin
  • N-(2-Hydroxyethyl)palmitamide
  • N-(2-Hydroxyethyl)palmitic amide
  • Palmitic acid monoethanolamide
  • N-(2-Hydroxyethyl)hexadecanamide, Palmidrol, PEA
  • Palmitoylethanolamide - CAS 544-31-0 - Calbiochem
  • PALMITOYLETHANOLIDE
  • Palmitoylethanolamide 544-31-0 Palmidrol
  • Palmidrol 544-31-0 N-(2-Hydroxyethyl)hexadecanamide
  • 2-(palmitoylamino)ethanol
  • HexadecanaMide,N-(2-hydroxyethyl)-
  • Palmidrol (Palmitamide MEA)
  • AM 3112
  • Palmitoylethanolamide(PEA)
  • Palmitoylethanolamide/Pea Powder
  • Loramine P 256
  • Mackpeart DR 14V
  • N-palmitoylethanolamine
  • Palmitoylethanolamide micro (PEA Micro)
  • Hexadecamide ethanol
  • High quality Blue Lotus Leaf Extract 200:1
  • PALMITOYLETHANOLAMIDE ISO 9001:2015 REACH
  • Cetylamide ethanol
  • 544-31-0
  • 554-31-0
  • C18N37NO2
  • Cannabinoid
  • Cannabinoid receptor
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