(S,R,S)-AHPC-PEG1-NH2 hydrochloride

(S,R,S)-AHPC-PEG1-NH2 hydrochloride Struktur
CAS-Nr.
Englisch Name:
(S,R,S)-AHPC-PEG1-NH2 hydrochloride
Synonyma:
(S,R,S)-AHPC-PEG1-NH2 hydrochloride
CBNumber:
CB14846306
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

(S,R,S)-AHPC-PEG1-NH2 hydrochloride Eigenschaften

storage temp. 
2-8°C

Sicherheit

(S,R,S)-AHPC-PEG1-NH2 hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Protein degrader builiding block (S,R,S)-AHPC-PEG1-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

(S,R,S)-AHPC-PEG1-NH2 hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(S,R,S)-AHPC-PEG1-NH2 hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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