CHOLERA TOXIN A SUBUNIT FROM VIBRIO*CHOLERAE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R21/22:Gesundheitsschädlich bei Berührung mit der Haut und beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S7:Behälter dicht geschlossen halten.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Verwenden
Cholera Toxin A Subunit from
Vibrio cholerae has been used as a specific probe for trimeric G proteins in membrane motility assays.
Allgemeine Beschreibung
Cholera Toxin (CT) is secreted by
Vibrio cholerae. CT upregulates cell surface molecules, such as co-stimulatory molecules and chemokine receptors in antigen presenting cells(APCs), murine and human dendritic cells (DCs). It enhances the secretion of interleukin 1 (IL-1) from macrophages and stimulates their APC function. CT also functions as an immunomodulator. It is associated with watery diarrhoea, which is characteristic of cholera infection.
Biochem/physiol Actions
Catalyzes ADP-ribosylation of the α-subunit of G proteins, reducing GTPase activity and activating the α-subunit; also catalyzes ADP-ribosylation of cell membrane adenylyl cyclase
CHOLERA TOXIN A SUBUNIT FROM VIBRIO*CHOLERAE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
