DANTROLENE

DANTROLENE Struktur
85008-71-5
CAS-Nr.
85008-71-5
Englisch Name:
DANTROLENE
Synonyma:
DANTROLENE;DANTROLENE USP/EP/BP;Dantrolene free base;DANTROLENE FREE BASE (FOR R&D ONLY);2,4-Imidazolidinedione,1-[[[4-(4-nitrophenyl)-2-furanyl]meth...
CBNumber:
CB2158286
Summenformel:
C14H10N4O5
Molgewicht:
314.25
MOL-Datei:
85008-71-5.mol

DANTROLENE Eigenschaften

Schmelzpunkt:
>236°C (dec.)
Dichte
1.57±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
Löslichkeit
DMSO (Slightly), Methanol (Very Slightly, Sonicated)
Aggregatzustand
Solid
pka
pKa 7.5 (Uncertain)
Farbe
Yellow to Dark Yellow
Stabilität:
Hygroscopic

Sicherheit

DANTROLENE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Dantrolene is a drug that causes spastic muscle contraction. Unlike other muscle relaxants, it has a direct effect on the contractile mechanism by interfering in the process of calcium ion release from the sarcoplasmic reticulum. This results in a lack of coordination in the mechanism of excitation––contraction of skeletal muscle, which has a greater effect on fast muscle fibers than on slow muscle fibers.

Verwenden

Dantrolene is used for controlling the onset of clinical spasticity resulting from serious clinical cases such as wounds, paralysis, cerebral palsy, and disseminated sclerosis. Synonyms of this drug are dantrium and danlen.

Biologische Funktion

The site of action of dantrolene is believed to be at the sarcoplasmic reticulum in skeletal muscle cells. Dantrolene binds to a calcium channel protein (ryanodine receptor) on the sarcoplasmic reticulum to close the channel and inhibit the release of calcium; the alkaloid ryanodine activates the same receptor to open the channel.

Mechanism of action

Dantrolene is believed to act directly on the contractile mechanism of skeletal muscle to decrease the force of contraction in the absence of any demonstrated effects on neural pathways, on the neuromuscular junction, or on the excitable properties of the muscle fiber membranes. Cardiac muscle and smooth muscle are minimally affected by dantrolene, likely because calcium release from sarcoplasmic reticulum of these muscle cell types occurs via a mechanism that differs from skeletal muscle. The muscle relaxant effect of dantrolene on skeletal muscle, however, is not specific, and generalized muscle weakness occurs as a major adverse side effect. Like other hydantoins, dantrolene is a weak base (pKa = 7.5) that can cross the blood-brain barrier; thus, CNS depressant side effects (e.g., sedation) are common. Dantrolene sodium salt is slowly absorbed from the gastrointestinal tract. The mean half-life of the drug in adults is approximately 9 hours after a 100-mg dose. It is slowly metabolized by the liver to give the 5-hydroxy and acetamido (nitro reduction and acetylation) metabolites, as well as unchanged drug, excreted in the urine.

Clinical Use

Dantrolene is a hydantoin derivative that acts peripherally to reduce spasticity and is indicated for use in spinal cord injury, stroke, cerebral palsy, and multiple sclerosis.

DANTROLENE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


DANTROLENE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 19)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 29016 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418684 +8618949823763
sales@tnjchem.com China 25363 58
Auschemicals Pty Ltd
+61406202619
info@auschemicals.com Australia 431 58
Hunan Furui Biopharma Technology Co., Ltd. 15902102743
shelley@furuipharma.com China 435 55
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973186 4009686088
3193328036@qq.com China 18352 68
Chengdu Saint - Kay Biotechnology Co., Ltd. 028-85157043 15882256948
676046971@qq.com China 4392 58
Wuhan Yuancheng Gongchuang Technology Co., Ltd. 17683743113
1414717232@qq.com China 6167 58

85008-71-5()Verwandte Suche:


  • DANTROLENE
  • DANTROLENE FREE BASE (FOR R&D ONLY)
  • Dantrolene free base
  • DANTROLENE USP/EP/BP
  • 2,4-Imidazolidinedione,1-[[[4-(4-nitrophenyl)-2-furanyl]meth...
  • 85008-71-5
  • C14H10N4O5
Copyright 2019 © ChemicalBook. All rights reserved