Anti-mucolipin 1 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project
(www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these
protocols and other useful information about Prestige Antibodies and the HPA, visit .
Allgemeine Beschreibung
The gene MCOLN1 (mucolipin-1) is mapped to human chromosome 19p13. The encoded protein is mainly present within late endosomes/lysosomes. The gene is widely expressed in human tissues.
Biochem/physiol Actions
MCOLN1 (mucolipin-1) is a lysosomal Ca2+ release channel. It regulates lysosome biogenesis as well as reformation, partly by activating calmodulin. It also helps in redistribution of Fe2+ between the lysosomes and the cytoplasm, thereby regulating reactive oxygen species production and mitochondrial deterioration. Mutations in this gene causes mucolipidosis type IV, a lysosomal storage disorder. MCOLN1 might also be involved with Alzheimer′s disease and HIV.
Anti-mucolipin 1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
