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N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide

N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Struktur
1557267-42-1
CAS-Nr.
1557267-42-1
Englisch Name:
N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide
Synonyma:
CS-2348;Avitinib;Avi Tini;Abivertinib;Avitinib (AC0010);Avitinib free base;Avitinib Abivertinib;Avitinib(AC0010/AC0010MA);N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide;N-{3-[(2-{[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}prop-2-enamide
CBNumber:
CB23051748
Summenformel:
C26H26FN7O2
Molgewicht:
487.53
MOL-Datei:
1557267-42-1.mol
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N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Eigenschaften

Dichte
1.365±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
Löslichkeit
DMSO:30.0(Max Conc. mg/mL);61.53(Max Conc. mM)
Aggregatzustand
A crystalline solid
pka
12.48±0.50(Predicted)

Sicherheit

N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Avitinib is a pyrrolopyrimidine-based, irreversible inhibitor of the epidermal growth factor receptor (EGFR). It is selective for EGFR-active and T790M mutations, exhibiting a 298-fold increase in potency compared with wild-type EGFR. In a xenograft model, oral administration of 500 mg/kg avitinib was shown to result in complete remission of tumors with EGFR-active and T790M mutations.

N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 75)Lieferanten
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
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InvivoChem 		+1-708-310-1919 +1-13798911105
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TargetMol Chemicals Inc. 		+1-781-999-5354
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ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
  • Avitinib
  • 2-Propenamide, N-[3-[[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]-
  • N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide
  • Avi Tini
  • Avitinib(AC0010/AC0010MA)
  • Avitinib free base
  • Avitinib (AC0010)
  • Abivertinib
  • CS-2348
  • Epidermal growth factor receptor,Bruton tyrosine kinase,AC-0010,Avitinib,HER1,Inhibitor,EGFR,Btk,AC 0010,Abivertinib,inhibit,ErbB-1
  • N-{3-[(2-{[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}prop-2-enamide
  • Avitinib Abivertinib
  • 1557267-42-1
  • 557267-42-1
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