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PROSTAGLANDIN D2

PROSTAGLANDIN D2 Struktur
41598-07-6
CAS-Nr.
41598-07-6
Englisch Name:
PROSTAGLANDIN D2
Synonyma:
PGDS;PGD2;Prostaglandin D?;PROSTAGLANDIN D2;PROSTAGLANDINS D2;PGD2 (Prostaglandin D2);RP23-47P18.11-006, 21kDa;11-dehydroprostaglandinf2-alpha;Prostaglandin D2 MaxSpecStandard;prostaglandin D2 synthase (brain)
CBNumber:
CB2433095
Summenformel:
C20H32O5
Molgewicht:
352.47
MOL-Datei:
41598-07-6.mol
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PROSTAGLANDIN D2 Eigenschaften

Schmelzpunkt:
68°C
Siedepunkt:
406.07°C (rough estimate)
alpha 
+7.5°(D/21℃)(c=1,THF)
Dichte
1.0601 (rough estimate)
Brechungsindex
1.6120 (estimate)
storage temp. 
-20°C
Löslichkeit
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly), THF (Slightly)
pka
4.76±0.10(Predicted)
Aggregatzustand
White solid
Farbe
White to Light Orange
BRN 
2170623
Stabilität:
Light Sensitive
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T
R-Sätze: 60-22
S-Sätze: 53-22-26-36
WGK Germany  3
RTECS-Nr. UK7930000
F  10
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H360 Kann die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" />
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

PROSTAGLANDIN D2 Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.
R22:Gesundheitsschädlich beim Verschlucken.

S-Sätze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD2 is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 inhibits human ovarian tumor cell proliferation with an IC50 of 6.8 μM.

Verwenden

Prostaglandin D2 is a fatty acid compound present in the human body. Elevated levels of localized Prostaglandin D2 has been linked to hair loss and growth inhibition. It has also been seen to contribute to the activity of allergic asthma.

Definition

ChEBI: A member of the class of prostaglandins D that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9 and 15 and an oxo group at position 11 (the 5Z,9alpha,13E,15S- s ereoisomer).

PROSTAGLANDIN D2 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Prosta-5,13-dien-1-oic acid, 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-15-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-11-oxo-, (5Z,9α,13E,15S)- (9CI) Prosta-5,13-dien-1-oic acid, 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-15-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-11-hydroxy-, (5Z,9α,11α,13E,15S)- (9CI) Prosta-5,13-dien-1-oic acid, 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-15-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-11-hydroxy-, methyl ester, (5Z,9α,11α,13E,15S)- (9CI) Prosta-5,13-dien-1-oic acid, 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-15-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-11-[(tetrahydro-2H-pyran-2-yl)oxy]-, methyl ester, (5Z,9α,11α,13E,15S)- (9CI) Prosta-5,13-dien-1-oic acid, 15-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-9-hydroxy-11-[(tetrahydro-2H-pyran-2-yl)oxy]-, methyl ester, (5Z,9α,11α,13E,15S)- (9CI) 5-Heptynoic acid, 7-oxo-, methyl ester 2H-Pyran, tetrahydro-2-[[(1S)-1-[(1E)-2-iodoethenyl]hexyl]oxy]- (4R)-(+)-T-BUTYLDIMETHYLSILOXY-2-CYCLOPENTEN-1-ONE

Downstream Produkte

PROSTAGLANDIN D2 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 68)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674;
 laboratory@coreychem.com China 30255 58
Aladdin Scientific 		+1-833-552-7181
sales@aladdinsci.com United States 57511 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
 jkinfo@jkchemical.com China 94838 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15848 69
Chemsky（shanghai）International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32344 50
Syntechem Co.,Ltd
info@syntechem.com China 12990 57
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185
 sales-cpd@caerulumpharma.com China 3421 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 18112977050
 cb6@aikonchem.com China 16687 50
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51471 80

41598-07-6()Verwandte Suche:

Dinatrium-3,4,5,6-tetrachlor-2-(2,4,5,7-tetraiod-6-oxido-3-oxoxanthen-9-yl)benzoat Dinoproston myo-Inosit Alprostadil Fluprostenol Pent-2-yn-1-ol
  • 9,15-dihydroxy-11-oxo-,(5z,9-alpha,13e,15s)-prosta-13-dien-1-oicacid
  • prostaglandin D2 cell culture tested
  • prostaglandind2synthetichygroscopic
  • (5z,9α,13e,15s)-9,15-dihydroxy-11-oxoprosta-5,13-dien-1-oic-acid
  • 7-[(1R,2R,5S)-5-hydroxy-2-[(3S)-3-hydroxyoct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid
  • PGD2, (5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic-acid
  • (5Z,13E,15S)-9α,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic acid
  • Prostaglandin D2,(5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic-acid, PGD2
  • Prostaglandin D2 Lipid Maps MS Standard
  • (Z)-7-((1R,2R,5S)-5-hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-3-oxocyclopentyl)hept-5-enoic acid
  • Anti-Ptgds antibody produced in goat
  • PGDS
  • prostaglandin D2 synthase (brain)
  • RP23-47P18.11-006, 21kDa
  • PGD2 (Prostaglandin D2)
  • Prostaglandin D?
  • PROSTAGLANDIN D2
  • PROSTAGLANDINS D2
  • PGD2
  • 9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,13E-DIEN-1-OIC ACID
  • [5Z,9ALPHA,13E,15S]9,15-DIHYDROXY-11-OXOPROSTA-5,13-DIEN-1-OIC ACID
  • 11-dehydroprostaglandinf2-alpha
  • Prostaglandin D2 MaxSpecStandard
  • Prostaglandin D - CAS 41598-07-6 - Calbiochem
  • Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, (5Z,9α,13E,15S)-
  • 41598-07-6
  • Fatty Acids
  • Prostaglandins
  • Lipids
  • BioChemical
  • Biochemicals and Reagents
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