Human Dermal Fibroblasts: HDF, adult

Human Dermal Fibroblasts: HDF, adult Struktur
CAS-Nr.
Englisch Name:
Human Dermal Fibroblasts: HDF, adult
Synonyma:
Human Dermal Fibroblasts: HDF, adult
CBNumber:
CB24670034
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

Human Dermal Fibroblasts: HDF, adult Eigenschaften

Sicherheit

Human Dermal Fibroblasts: HDF, adult Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

injury recovery, connective tissue research, laminin and fibronectin production, extracellular matrix, tissue organization, wound healing, fibroblasts growth factor response

Allgemeine Beschreibung

Dermal Fibroblasts are responsible for producing the extracellular matrix forming the connective tissue of the skin, and play a crucial role during wound healing. HDF provide an excellent model system to study many aspects of cell physiology, and have been utilized in dozens of research publications, particularly those related to skin biology and reprogramming/induced pluripotency studies. HDF were used to create, along with human synovyocytes, induced pluripotent stem cells (iPSC) by using the now classic “Yamanaka cocktail” of Oct3/4, Sox2, Klf4, and c-Myc, the discovery for which Dr. Shinya Yamanaka was awarded the Nobel Prize in 2012 (Takanashi, 2007; 2009), and to characterize iPSC general properties, miRNA expression profiles and differentiation potential (Hayashi, 2010; Ohta, 2011; Koyanagi-Aoi, 2013; Noguchi, 20130; Razak, 2013; Sakurai, 2013; Tanaka, 2013; Yanagida, 2013)

Human Dermal Fibroblasts: HDF, adult Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


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