activating transcription factor 1

activating transcription factor 1 Struktur
CAS-Nr.
Englisch Name:
activating transcription factor 1
Synonyma:
ATF1;TCR-ATF1;GDNF from rat;TREB36 protein;GDNF from mouse;activating transcription factor 1;Recombinant Human ATF1 Protein, His Tag;Cyclic-AMP-dependent transcription factor ATF-1;Anti-ATF1, C-Terminal antibody produced in rabbit
CBNumber:
CB31355058
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

activating transcription factor 1 Eigenschaften

storage temp. 
-20°C
Aggregatzustand
lyophilized
Farbe
white to off-white
Biologische Quelle
mouse

Sicherheit

WGK Germany  3

activating transcription factor 1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

GDNF from mouse has been used for stimulating primary murine cultures of dorsal root ganglion (DRG) neurons.

Allgemeine Beschreibung

GDNF (glial cell line derived neurotrophic factor) is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. The functional murine GDNF ligand is a disulfide-linked homodimer, of two 15.1kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, one of which is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.

Biochem/physiol Actions

GDNF (glial cell line derived neurotrophic factor) signals through a multicomponent receptor system, composed of a RET (receptor tyrosine kinase) and one of the four GFR-α (α1-α4) receptors (GDNF family receptors). GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson′s disease monkey model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. It might also be involved in the treatment of non-alcoholic fatty liver disease. GDNF is needed for proper spermatogonial stem cell survival and proliferation.

activating transcription factor 1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


activating transcription factor 1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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  • Anti-ATF1, C-Terminal antibody produced in rabbit
  • activating transcription factor 1
  • TREB36 protein
  • GDNF from mouse
  • GDNF from rat
  • ATF1
  • Cyclic-AMP-dependent transcription factor ATF-1
  • TCR-ATF1
  • Recombinant Human ATF1 Protein, His Tag
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