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N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide

N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide Struktur
1346528-50-4
CAS-Nr.
1346528-50-4
Englisch Name:
N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide
Synonyma:
CS-2830;JNJ42165279;JNJ-42165279 (JNJ-5279);JNJ 42165279;JNJ42165279;Fatty acid amide hydrolase,inhibit,Autophagy,JNJ 42165279,FAAH,JNJ-42165279,Inhibitor;N-(4-Chloro-3-pyridinyl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-1-piperazinecarboxamide;1-Piperazinecarboxamide, N-(4-chloro-3-pyridinyl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-;N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide
CBNumber:
CB32671063
Summenformel:
C18H17ClF2N4O3
Molgewicht:
410.8
MOL-Datei:
1346528-50-4.mol
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N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide Eigenschaften

Siedepunkt:
541.2±50.0 °C(Predicted)
Dichte
1.52±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
Löslichkeit
≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
Aggregatzustand
crystalline solid
pka
12.91±0.20(Predicted)

Sicherheit

N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

JNJ-42165279 is a potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH; IC50s = 70 and 313 nM for human and rat forms, respectively). It displays selectivity for FAAH over a panel of other enzymes, receptors, transporters, and ion channels. JNJ-42165279 is active in vivo, blocking FAAH activity in brain and periphery of rats and raising concentrations of anandamide , oleoyl ethanolamide , and palmitoyl ethanolamide . It is also efficacious in the spinal nerve ligation model of neuropathic pain.

N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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  • N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide
  • N-(4-Chloro-3-pyridinyl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-1-piperazinecarboxamide
  • JNJ42165279
  • CS-2830
  • JNJ 42165279;JNJ42165279
  • 1-Piperazinecarboxamide, N-(4-chloro-3-pyridinyl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-
  • JNJ-42165279 (JNJ-5279)
  • Fatty acid amide hydrolase,inhibit,Autophagy,JNJ 42165279,FAAH,JNJ-42165279,Inhibitor
  • 1346528-50-4
  • 1356528-50-4
  • C18H17ClF2N4O3
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