Calcineurin Inhibitor VIII, CN585 - CAS 1213234-31-1 - Calbiochem

Calcineurin Inhibitor VIII, CN585 - CAS 1213234-31-1 - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

A cell-permeable pyrimidine compound that is shown to inhibit the calcineurin (PP2B)-catalyzed dephosphorylation of RII phosphopeptide (Cat. No. 207008), but not pNPP (Cat. Nos. 4876, 487600, 487655, 487663, 487666), in a reversible, calmodulin-independent, and substrate-noncompetitive manner (IC₅₀ = 3.5 μM; K_i = 3.8 μM), while exhibiting little activity against PP1, PP2A, or PP2C even at concentrations as high as 100 μM. Unlike CsA (Cat. No. 239835) and FK506 (Cat. No. 342500), CN585 does not require Cyp A (Cat. No. 239777) and FKBP family immunophilins for PP2B inhibition, nor does CN585 inhibit the peptidyl prolyl cis/trans isomerase (PPIase) activity of Cyp18, FKBP12 (Cat. No. 325902), and Pin1, although binding studies indicate that CN585 and Cyp18/CsA target a common or overlapping binding sites on the catalytic subunit of PP2B. CN585, at 30 μM, is shown to effectively block NFAT nuclear translocation in HeLa cells, NFAT transcription activity in Jurkat cells (IC₅₀ = 10 μM), as well as IL-2 production in PBMC (IC₅₀ = 13 μM) upon PMA/ionomycin stimulation.

Calcineurin Inhibitor VIII, CN585 - CAS 1213234-31-1 - Calbiochem Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Calcineurin Inhibitor VIII, CN585 - CAS 1213234-31-1 - Calbiochem Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80

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• Calcineurin Inhibitor VIII, CN585 - CAS 1213234-31-1 - Calbiochem
• Ethanamine, 2-[[6-(3,4-dichlorophenyl)-2-phenyl-4-pyrimidinyl]thio]-N,N-dimethyl-
• 1213234-31-1