Calcineurin Inhibitor VIII, CN585 - CAS 1213234-31-1 - Calbiochem

Calcineurin Inhibitor VIII, CN585 - CAS 1213234-31-1 - Calbiochem Struktur
1213234-31-1
CAS-Nr.
1213234-31-1
Englisch Name:
Calcineurin Inhibitor VIII, CN585 - CAS 1213234-31-1 - Calbiochem
Synonyma:
Calcineurin Inhibitor VIII, CN585 - CAS 1213234-31-1 - Calbiochem;Ethanamine, 2-[[6-(3,4-dichlorophenyl)-2-phenyl-4-pyrimidinyl]thio]-N,N-dimethyl-
CBNumber:
CB34813779
Summenformel:
C20H19Cl2N3S
Molgewicht:
404.36
MOL-Datei:
1213234-31-1.mol

Calcineurin Inhibitor VIII, CN585 - CAS 1213234-31-1 - Calbiochem Eigenschaften

Siedepunkt:
471.1±45.0 °C(Predicted)
Dichte
1.33±0.1 g/cm3(Predicted)
pka
8.34±0.28(Predicted)

Sicherheit

Calcineurin Inhibitor VIII, CN585 - CAS 1213234-31-1 - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

A cell-permeable pyrimidine compound that is shown to inhibit the calcineurin (PP2B)-catalyzed dephosphorylation of RII phosphopeptide (Cat. No. 207008), but not pNPP (Cat. Nos. 4876, 487600, 487655, 487663, 487666), in a reversible, calmodulin-independent, and substrate-noncompetitive manner (IC50 = 3.5 μM; Ki = 3.8 μM), while exhibiting little activity against PP1, PP2A, or PP2C even at concentrations as high as 100 μM. Unlike CsA (Cat. No. 239835) and FK506 (Cat. No. 342500), CN585 does not require Cyp A (Cat. No. 239777) and FKBP family immunophilins for PP2B inhibition, nor does CN585 inhibit the peptidyl prolyl cis/trans isomerase (PPIase) activity of Cyp18, FKBP12 (Cat. No. 325902), and Pin1, although binding studies indicate that CN585 and Cyp18/CsA target a common or overlapping binding sites on the catalytic subunit of PP2B. CN585, at 30 μM, is shown to effectively block NFAT nuclear translocation in HeLa cells, NFAT transcription activity in Jurkat cells (IC50 = 10 μM), as well as IL-2 production in PBMC (IC50 = 13 μM) upon PMA/ionomycin stimulation.

Calcineurin Inhibitor VIII, CN585 - CAS 1213234-31-1 - Calbiochem Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Calcineurin Inhibitor VIII, CN585 - CAS 1213234-31-1 - Calbiochem Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 2)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Sigma-Aldrich 021-61415566 800-8193336
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  • Calcineurin Inhibitor VIII, CN585 - CAS 1213234-31-1 - Calbiochem
  • Ethanamine, 2-[[6-(3,4-dichlorophenyl)-2-phenyl-4-pyrimidinyl]thio]-N,N-dimethyl-
  • 1213234-31-1
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