6-CHLORO-2-PICOLINIC ACID METHYL ESTER
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- CAS-Nr.
- 6636-55-1
- Englisch Name:
- 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
- Synonyma:
- AKOS BBS-00004651;Sorafenib Impurity 117;methyl 6-chloropicolinate;6-Chloropicolinic acid methyl ester;methyl (6-chloropyridin-2-yl)acetate;methyl 6-chloro-2-pyridinecarboxylate;METHYL 6-CHLOROPYRIDINE-2-CARBOXYLATE;2-chloropyridine-6-carboxylate methyl;methyl 2-(6-chloropyridin-2-yl)acetate;6-CHLORO-2-PICOLINIC ACID METHYL ESTER
- CBNumber:
- CB3780710
- Summenformel:
- C7H6ClNO2
- Molgewicht:
- 171.58
- MOL-Datei:
- 6636-55-1.mol
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6-CHLORO-2-PICOLINIC ACID METHYL ESTER Eigenschaften
- Schmelzpunkt:
- 93-94°
- Siedepunkt:
- 275.8±20.0 °C(Predicted)
- Dichte
- 1.294±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -1.03±0.10(Predicted)
- Aggregatzustand
- Solid
- Farbe
- Pale yellow
- Wasserlöslichkeit
- Slightly soluble in water.
6-CHLORO-2-PICOLINIC ACID METHYL ESTER Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Methyl 6-chloropyridine-2-carboxylate was coupled with 2-(trimethylstannyl)pyridine to afford methyl 2,2?-bipyridine-6-carboxylate.
Synthesis Reference(s)
Synthetic Communications, 14, p. 77, 1984
DOI: 10.1080/00397918408060867
Synthese
6-Chloro-2-picolinic acid methyl ester is prepared by the reaction of methanol and 6-Chloropicolinic acid. The specific synthesis steps are as follows:
Add thionyl chloride (3.7 ml, 50.8 mmol) to a solution of 6-chloropicolinic acid (4.0 g, 25.4 mmol) in methanol (85 ml) at 0 C. Stir the resultant solution for 15 minutes at 0 C, 0.5 hours at room temperature, and 6 hours at 50 C. Concentrate the reaction in vacuo and dilute with CHCl3 (150ml). Wash the organic solution with saturated aqueous sodium bicarbonate (3 x 100 ml), and brine (1 x 100 ml) and dry with sodium sulfate. Filtration and concentration afford methyl 6-chloropicolinate 4.38 g (100 percent) as a white solid. 1H NMR (CDCl3): δ 8.05 (m, 1H), 7.73 (m, 1H), 7.42 (m, 1H), 3.95 (s, 3H).
6-CHLORO-2-PICOLINIC ACID METHYL ESTER Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
6-CHLORO-2-PICOLINIC ACID METHYL ESTER Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 212)Lieferanten
6636-55-1()Verwandte Suche:
- Methyl 6-Chloropyridine-2-carboxylate, 97+%
- METHYL 6-CHLOROPYRIDINE-2-CARBOXYLATE
- AKOS BBS-00004651
- 6-CHLOROPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
- 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
- 6-Chloro-2-pyridinecarboxylic acid methyl ester
- 6-Chloropicolinic acid methyl ester
- 2-Pyridinecarboxylic acid, 6-chloro-, methyl ester
- methyl 6-chloro-2-pyridinecarboxylate
- methyl 2-(6-chloropyridin-2-yl)acetate
- methyl 6-chloropicolinate
- methyl (6-chloropyridin-2-yl)acetate
- 2-chloropyridine-6-carboxylate methyl
- 6-chloro-2-picolonic acid methyl ester
- Methyl 6-chloropicolinate, 2-Chloro-6-(methoxycarbonyl)pyridine
- 6-Chloro-2-picolinic acid methyl ester Solution
- Methyl 6-Chloro-2-pyridinecarboxylate >
- Methyl6-chloropyridine-2-carboxylate,95%
- 6-CHLORO-2-PICOLINIC ACID METHYL ESTER ISO 9001：2015 REACH
- Sorafenib Impurity 117
- 6636-55-1
- Picolinic acid series
