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(-)-ANABASINE Produkt Beschreibung

(-)-ANABASINE Struktur
13078-04-1
CAS-Nr.
13078-04-1
Englisch Name:
(-)-ANABASINE
Synonyma:
ANABASINE;NEONICOTINE;(-)-ANABASINE;(n)-anabasine;Anabasine >=97%;L(-)-NEONICOTINE;Anabasine, Neonicotine;2-(3-PYRIDYL)PIPERIDINE;(±)-Anabasine, tech. 85%;Pyridine, 3-(2-piperidinyl)-
CBNumber:
CB4100643
Summenformel:
C10H14N2
Molgewicht:
162.23
MOL-Datei:
13078-04-1.mol

(-)-ANABASINE Eigenschaften

Schmelzpunkt:
9 °C
Siedepunkt:
270 °C
Dichte
1.05 g/mL at 25 °C(lit.)
Brechungsindex
1.5440
Flammpunkt:
93 °C
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit
H2O: 10 mg/mL
pka
8.98±0.10(Predicted)
Aggregatzustand
liquid
Farbe
colorless to yellow
Merck 
14,619
BRN 
82639
InChIKey
MTXSIJUGVMTTMU-UHFFFAOYSA-N
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T,Xn
R-Sätze: 23/24/25-36/37/38-25-20/21/22-51/53-27/28
S-Sätze: 36/37/39-45-26-36-57-27/28-23-20
RIDADR  UN 3140 6.1/PG 2
WGK Germany  3
RTECS-Nr. BV4375000
Hazard Note  Toxic
HazardClass  6.1
PackingGroup  I
HS Code  29339900
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H227 Combustible liquid Flammable liquids Category 4 Warnung P210, P280, P370+P378, P403+P235,P501
H300 Lebensgefahr bei Verschlucken. Akute Toxizität oral Kategorie 2 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H310 Lebensgefahr bei Hautkontakt. Acute toxicity,dermal Category 1, 2 Achtung P262, P264, P270, P280, P302+P350,P310, P322, P361, P363, P405, P501
H401 Toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 2 P273, P501
H411 Giftig für Wasserorganismen, mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 2
Sicherheit
P262 Nicht in die Augen, auf die Haut oder auf die Kleidung gelangen lassen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P405 Unter Verschluss aufbewahren.

(-)-ANABASINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R25:Giftig beim Verschlucken.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Anatabine is an alkaloid found in the root, fibrous roots, or bark of Alangium chinense (Lour) Harms. The herb was recorded in “Jianyi Bencao,” “Bencao Gangmu Shiyi,” and “Zhi Wu Ming Shi Tu Kao.” Alangium chinense is widely distributed in the east and south of China. It is also called “Bailongxu” in Shaanxi, Yunnan, and Guizhou provinces, “Baijintiao” in Guangxi province, and “Bajiaowutong,” “Bajiaojinpan,” or “Laolongxu” in Jiangxi and Hubei provinces. This plant is commonly used as a traditional Chinese medicine. The Alangium species includes more than 30 plants which are distributed in Asia, Oceania, and Africa. Nine of these plants are distributed in China. The root and the stem parts of Alangium plants are toxic.

Chemische Eigenschaften

Colourless Oil

Physikalische Eigenschaften

Appearance: Colorless to yellow liquid. Solubility: Soluble in water and common organic solvents. Boiling point: 110?°C. Refractive index: 1.5418. Density: 1.0516?g cm?3.

History

Alangium chinense contains alkaloids, sugars, saponins, steroids, triterpenes, anthraquinones and their glycosides, and other ingredients. In 1974, dl-anabasine was isolated from the fibrous roots of Alangium chinense . Four isoquinoline alkaloids including two new alkaloids (?)-10-O-dimethyl-eugenol base and 10-O-dimethyl-eugenol base were isolated. P-amyrin acetate, triacontanol, and β-sitosterol were then found in its leaves . Seven glycosides were isolated from the water-soluble fraction of dried leaves of Alangium chinense, and eight glycosides were also isolated from the n-butanol soluble part . Three new lignincompounds including 2-O-(β-apio-furanosyl)-β-glucoside, E ferulic acid ester, and Z ferulic acid ester were extracted from Alangium chinense, and their structures were determined. Nakamoto et?al. extracted 7-O-acetylmaleic acid from Alangium chinense and determined the structure. There are also long-chain fatty acids and short-chain alkanes in Alangium chinense leaves. The volatile oil was then analyzed, and 59 components are identified by GC-MS.?The total alkaloid content in the Alangium chinense was found to be fibrous root > fine root > coarse root > branch wood > leaf.

Verwenden

A nicotinic receptor agonist

Verwenden

insecticide

Definition

ChEBI: A pyridine alkaloid that is pyridine substituted by a piperidin-2-yl group at position 3.

Pharmakologie

Alangium plants have wide pharmacological effects including muscle relaxation, central inhibition, anticancer, antibacterial, and so on. The “Jisong-II” injection has presynaptic and postsynaptic effects on the neuromuscular junction, and it acts as noncompetitive muscular relaxant . In 1979, the respiratory suppression experiments showed that Alangium chinense is a central nervous system depressant . The extract of Alangium chinense significantly inhibits the growth of P388 lymphoblastic leukemia and Gardner lymphosarcoma in mice, but it has no effect on Gross virus-induced leukemia, Warner myelomonocytic leukemia, and B16 melanoma . Another study reported that the anabasine could excite respiratory similar to nicotine and lobeline. Anabasine also induces high blood pressure and bradycardia. The components in the Alangium chinense extract can bind to the M, 5-HT and dopamine receptors indicating that Alangium chinense affects the central nervous system.

Clinical Use

The Alangium chinense was used for treating rheumatoid arthritis.

(-)-ANABASINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(-)-ANABASINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 99)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29960 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 19969 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63726 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47496 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
13580539051
joe@yuhengpharm.com CHINA 21151 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
13588875226 86-571-88216897、88216896
86-571-88216895 sales@hzclap.com CHINA 6469 58
ShenZhen Ipure Biology import and export company co.,ltd
18071025641 18071025641
eric@ipurechemical.com CHINA 11336 58

13078-04-1()Verwandte Suche:


  • (±)-Anabasine, tech. 85%
  • 3-(2-Piperidinyl)pyridine, Neonicotine
  • 2-(3-Pyridyl)piperidine, Neonicotine
  • 3-piperidin-2-ylpyridine hydrochloride
  • (±)-Anabasine,3-(2-Piperidinyl)pyridine, Neonicotine
  • Anabasine,2-(3-Pyridyl)piperidine, Neonicotine
  • Anabasine, Neonicotine, 2-(Pyridin-3-yl)piperidine
  • Nicotine EP Impurity G (Anabasine )
  • Anabasine >=97%
  • 3-(2-piperidyl)pyridine hydrochloride
  • (S)-1,2,3,4,5,6-HEXAHYDRO-[2,3']BIPYRIDINYL
  • (S)-(-)-2-(3-PYRIDYL)PIPERIDINE
  • NEONICOTINE
  • (R,S)-1,2,3,4,5,6-Hexahydro-[2,3’]bipyridinyl
  • 1,2,3,4,5,6-hexahydro-2,3’-bipyridine
  • L(-)-NEONICOTINE
  • (-)-ANABASINE
  • ANABASINE
  • 2-(3-PYRIDYL)PIPERIDINE
  • Neonicotine~2-(3-Pyridyl)piperidine
  • Anabasine, Neonicotine
  • (n)-anabasine
  • Pyridine, 3-(2-piperidinyl)-
  • 13078-04-1
  • Aromatics Compounds
  • Alkaloids
  • Pyrans, Piperidines &Piperazines
  • Neuroscience
  • Neurotransmission
  • Neurotransmitters
  • Pesticides &
  • Pesticides Standards
  • Pyridines
  • Heterocycles
  • Nicotinic Acetylcholine Receptor Modulators
  • Agonists
  • Analytical Standards
  • Aromatics
  • Nicotine Derivatives
  • Pyrans, Piperidines & Piperazines
  • Analytical/Chromatography
  • AN-AZ
  • Bioactive Small Molecules
  • Botanicals
  • Building Blocks
  • C10
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Chemical Synthesis
  • Cholinergics
  • Chromatography
  • Environmental Standards
  • Heterocyclic Building Blocks
  • Insecticides
  • Ion Channels
  • Ligand-Gated Ion Channels
  • Metabolites
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