PD 404182
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- CAS-Nr.
- 72596-74-8
- Englisch Name:
- PD 404182
- Synonyma:
- PD 404,182;3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine;3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine;2H,6H-Pyrimido[1,2-c][1,3]benzothiazin-6-imine, 3,4-dihydro-;3，4-Dihydro-2H，6H-benzo[e]pyrimido[1，2-c][1，3]thiazin-6-imine;6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE
- CBNumber:
- CB4347334
- Summenformel:
- C11H11N3S
- Molgewicht:
- 217.29
- MOL-Datei:
- Mol file
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PD 404182 Eigenschaften
- Siedepunkt:
- 366.8±25.0 °C(Predicted)
- Dichte
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: ≥22 mg/mL, soluble
- pka
- 6.27±0.20(Predicted)
- Aggregatzustand
- powder
PD 404182 Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
PD 404182 is an inhibitor of SARS-CoV-2
Enzyminhibitor
This KDO-8-P synthase inhibitor and potential antibiotic (FW = 217.29 g/mol), also named 6H-6-imino(2,3,4,5-tetrahydropyrimido)[1,2-c][1,3] benzothiazine, is a slow, tight-binding agent that targets 3-deoxy-D-mannooctulosonate-8-phosphate synthase, an enzyme participating in the synthesis of 3-deoxy-D-manno-2-octulosonic acid (KDO). The latter is an essential component of LPS (lipopolysaccharide) in the outer membrane of Gramnegative bacteria. PD 404182 is an antiretroviral agent with submicromolarinhibitory activity against human immunodeficiency virus-1 (HIV-1) and HIV-2 infection. PD-404182 also potently inhibits dimethylarginine dimethylaminohydrolase isoform-1 (DDAH1), the human enzyme that degrades Asymmetric Dimethylarginine, or ADMA (See Asymmetric Dimethylarginine). Because ADMA inhibits nitric oxide synthesis and because ADMA levels are predictive for future cardiovascular disease, chronic use of PD-404182 is apt to have side-effects.
PD 404182 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
PD 404182 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 14)Lieferanten
- 6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE
- PD 404,182
- 3，4-Dihydro-2H，6H-benzo[e]pyrimido[1，2-c][1，3]thiazin-6-imine
- 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
- 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
- 2H,6H-Pyrimido[1,2-c][1,3]benzothiazin-6-imine, 3,4-dihydro-
- 72596-74-8
