ANTI-MUCIN-1, HUMAN Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-ETFA (AB1) antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.
Allgemeine Beschreibung
MUC1 (Mucin 1) is O-glycosylated, carbohydrate rich, transmembrane glycoprotein. It has approximately 13 members in the family. It is localized on the apical surface of mucosal epithelia in the lung, eye, breast and stomach. It is overexpressed in several epithelial cancers, including pancreatic ductal adenocarcinoma. It is a heterodimer consisting of N-terminal (MUC1-N) and C-terminal (MUC1-C) subunits. N-terminal (MUC1-N) end contains tandem repeats (VNTR) which forms the mucin component.
Biochem/physiol Actions
ETFA (electron-transfer-flavoprotein, α polypeptide) encodes a flavoprotein that belongs to ETF α-subunit/FixB family. It facilitates the catalysis of initial step of the mitochondrial fatty acid β-oxidation. Increase in the cellular levels of ETFA leads to activation of JNK1/2 and NFκB signaling modules which in turn facilitates the t-BHP induced apoptosis cascade and cell viability.
ANTI-MUCIN-1, HUMAN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
