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FLURITHROMYCIN Produkt Beschreibung

FLURITHROMYCIN Struktur
82664-20-8
CAS-Nr.
82664-20-8
Englisch Name:
FLURITHROMYCIN
Synonyma:
cl-932;p80206;C1-932;P-0501-A;FLURITHROMYCIN;fluritromicina;antibioticp80206;Huritromicina(sp);8-fluoroerythromycin;8-fluoro-erythromyci
CBNumber:
CB4467319
Summenformel:
C37H66FNO13
Molgewicht:
751.92
MOL-Datei:
82664-20-8.mol

FLURITHROMYCIN Eigenschaften

Sicherheit

Kennzeichnung gefährlicher F
R-Sätze: 10
S-Sätze: 16

FLURITHROMYCIN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R10:Entzündlich.

S-Sätze Betriebsanweisung:

S16:Von Zündquellen fernhalten - Nicht rauchen.

Verwenden

A fluorinated derivative of Erythromycin (E649950). A macrolide antibiotic.

Definition

ChEBI: An erythromycin derivative that is erythromycin A in which the hydrogen attached to the carbon at position 8 (alpha to the ketone carbonyl group) has been replaced by a fluorine. It has been used (generally as the corresponding monoethyl s ccinate ester) as an antibacterial drug.

Pharmazeutische Anwendungen

A semisynthetic derivative of erythromycin A, supplied for oral administration. It is stable at acid pH due to the presence of the fluorine atom at C-8 of the erythronolide A ring.
It is active against most streptococci (including Str. pneumoniae and Str. agalactiae; MIC50 0.03 mg/L), Mor. catarrhalis, N. gonorrhoeae (MIC50 0.04 mg/L), C. trachomatis (MIC 0.06– 0.125 mg/L), M. genitalium (MIC50 0.007 mg/L) and U. urealyticum (MIC50 0.03 mg/L). It has little or no activity against H. influenzae and M. hominis. Activity against anaerobes is similar to that of erythromycin A. It displays cross-resistance with erythromycin A.
A single 500 mg oral dose achieved a mean peak plasma concentration of 1.2–2 mg/L after 1–2 h. The apparent elimination half-life was 8 h and the volume of distribution 5.5 L/ kg. With repeated doses (500 mg orally every 8 h for 10 doses), plasma concentrations were 0.72 mg/L immediately before and 0.67 mg/L at 4 h after the last dose. Absorption is not significantly affected by food. After administration of a single 375 mg tablet of flurithromycin ethylsuccinate, the mean serum levels at 0.5 h were 0.43 ± 0.35 mg/L. The mean peak serum concentration (1.41 ± 0.49 mg/L) was achieved at 1 h. At 8 and 12 h, the serum levels were 0.14 (± 0.05) and 0.04 (± 0.04) mg/L, respectively. The apparent elimination half-life is 3.94 (± 1.42) h. The apparent half-life in artificial gastric juice was about 40 min.
It is generally well tolerated and has been used successfully for the treatment of lower respiratory tract infections. Availability is limited.

FLURITHROMYCIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


FLURITHROMYCIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 18)Lieferanten
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J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
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shanghai science Bio-Pharmceutical.co,ltd. 13482412995/13761402923 02157872719
02157872719 market@freefluor.com China 298 60
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15426 60
(CSR Factory)China Skyrun Industrial CO.,ltd Please Email
manager@chinaskyrun.com sales@chinaskyrun.com China 12123 58
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Advantage suppliers add cooperation QQ:577116998 szxys126@126.com China 54472 58
BOC Sciences 1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 10000 58
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  • 8-FluoroerythroMycin A
  • 8-fluoroerythromycin
  • antibioticp80206
  • cl-932
  • fluritromicina
  • p80206
  • FLURITHROMYCIN
  • C1-932
  • Huritromicina(sp)
  • P-0501-A
  • (8s)-8-fluoroerythromycina
  • 8-fluoro-erythromyci
  • 82664-20-8
  • C37H66FNO13
  • C37H66NO13F
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Carbohydrates & Derivatives
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