LDC7559

2407782-01-6

CAS-Nr.: 2407782-01-6

Englisch Name:: LDC7559

Synonyma:: LDC7559;LDC7559 ，S9622;LDC7559, 10 mM in DMSO;Inhibitor,Pyroptosis,LDC7559,inhibit,LDC 7559,LDC-7559;Acetamide, N-[2-(2-methoxyphenyl)-4H,10H-pyrazolo[5,1-c][1,4]benzoxazepin-7-yl]-;N-(2-(2-Methoxyphenyl)-4H,10H-benzo[f]pyrazolo[5,1-c][1,4]oxazepin-7-yl)acetamide;N-(2-(2-Methoxyphenyl)-4,10-dihydrobenzo[f]pyrazolo[5,1-c][1,4]oxazepin-7-yl)acetamide

CBNumber:: CB48096799

Summenformel:: C20H19N3O3

Molgewicht:: 349.38

MOL-Datei:: 2407782-01-6.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 45

LDC7559 Eigenschaften

Siedepunkt:: 596.3±50.0 °C(Predicted)

Dichte: 1.29±0.1 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: DMSO : ≥ 125 mg/mL (357.78 mM)

pka: 14.44±0.20(Predicted)

Aggregatzustand: Solid

Farbe: White to light yellow

InChI: InChI=1S/C20H19N3O3/c1-13(24)21-15-8-7-14-11-23-16(12-26-20(14)9-15)10-18(22-23)17-5-3-4-6-19(17)25-2/h3-10H,11-12H2,1-2H3,(H,21,24)

InChIKey: IFOIINXSFCQLOV-UHFFFAOYSA-N

SMILES: C(NC1C=C2OCC3=CC(C4=CC=CC=C4OC)=NN3CC2=CC=1)(=O)C

Sicherheit

LDC7559 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages.

in vitro

LDC7559 (1 and 5 μM) inhibits IL-1β release upon inflammasome activation, and significantly blocks the lethal effect of both human and murine GSDMD NT domains transfected into HEK293T cells.
LDC7559 functions directly through blocking the activity of the GSDMD NT domain, rather than interfering with the activation and cleavage process.

LDC7559 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

LDC7559 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 45)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10473	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39035	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	8510	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
Nanjing Xinmeihe Pharmaceutical Co., Ltd.	025-57672321 13739186949	yuanming@huashineltd.com	China	446	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3505	58

Acetamide, N-[2-(2-methoxyphenyl)-4H,10H-pyrazolo[5,1-c][1,4]benzoxazepin-7-yl]-
LDC7559
Inhibitor,Pyroptosis,LDC7559,inhibit,LDC 7559,LDC-7559
N-(2-(2-Methoxyphenyl)-4,10-dihydrobenzo[f]pyrazolo[5,1-c][1,4]oxazepin-7-yl)acetamide
LDC7559, 10 mM in DMSO
LDC7559 ，S9622
N-(2-(2-Methoxyphenyl)-4H,10H-benzo[f]pyrazolo[5,1-c][1,4]oxazepin-7-yl)acetamide
2407782-01-6