ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate

4450-98-0

CAS-Nr.: 4450-98-0

Englisch Name:: ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate

Synonyma:: 1-Ebpc;CP-10668;Nsc 229530;Aldose Reductase,inhibit,EBPC,Inhibitor;1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester;1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester;2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylMethyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester;1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-, ethyl ester

CBNumber:: CB51373216

Summenformel:: C14H15NO4

Molgewicht:: 261.27

MOL-Datei:: 4450-98-0.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 23

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Eigenschaften

Schmelzpunkt:: 135-136 °C

Siedepunkt:: 479.8±45.0 °C(Predicted)

Dichte: 1.340±0.06 g/cm3(Predicted)

storage temp.: room temp

Löslichkeit: DMSO: ≥10mg/mL

Aggregatzustand: white powder

pka: 4.50±1.00(Predicted)

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-41
S-Sätze:	26
WGK Germany	3
HazardClass	IRRITANT

Bildanzeige (GHS)

Alarmwort

Achtung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H302	Gesundheitsschädlich bei Verschlucken.	Akute Toxizität oral	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P270, P301+P312, P330, P501
H318	Verursacht schwere Augenschäden.	Schwere Augenschädigung	Kategorie 1	Achtung	src="/GHS05.jpg" width="20" height="20" />	P280, P305+P351+P338, P310

Sicherheit

P280	Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The human aldose reductase AKR1B1 is considered the rate limiting enzyme of the polyol pathway responsible for the conversion of glucose into sorbitol. It also acts as a highly efficient PGF_2α synthase in response to interleukin-1β. Increased aldose reductase expression has been associated with complications of diabetes and may contribute to reduced efficacy of certain chemotherapeutic drugs. EBPC is a potent, selective inhibitor of aldose reductase with an IC₅₀ value of 47 nM in vitro. Through its regulation of glucose metabolism, EBPC has been used to improve the cytotoxic effects of the anticancer agents doxorubicin and cisplatin in HeLa cervical carcinoma cells. EBPC also inhibits prostaglandin F_2α (PGF_2α) and PGE₂ production in human endometrial cells with an EC₅₀ value of 10 μM.

Verwenden

A highly specific aldose reductase inhibitor that has been shown to enhance HeLa cell sensitivity to chemotherapeutic drugs.

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 23)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Tetranov Biopharm	13526569071	sales@leadmedpharm.com	China	7891	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Aikon International Limited	025-66113011 13155353615	qzhang@aikonchem.com	China	15396	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58

4450-98-0()Verwandte Suche:

Ethyl-N-benzyl-β-alaninat

1-Ebpc
1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-, ethyl ester
Nsc 229530
1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester
1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester
2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylMethyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester
CP-10668
Aldose Reductase,inhibit,EBPC,Inhibitor
4450-98-0
Aromatics
Heterocycles
Inhibitors
Intermediates & Fine Chemicals
Pfizer Compounds
Pharmaceuticals