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2'-O-Methyladenosine

2'-O-Methyladenosine Struktur
2140-79-6
CAS-Nr.
2140-79-6
Englisch Name:
2'-O-Methyladenosine
Synonyma:
(2R,3R,4R,5R)-5-(6-AMino-9H-purin-9-yl)-2-(hydroxyMethyl)-4-Methoxytetrahydrofuran-3-ol;AMI;cordysinin B;OMe-rA;2'-OMe-A;2'-OMe-rA;2'-OMe-Ar;2'-O-Me-Ado;2'-OMe Adenosine;-O-Methyladenosine
CBNumber:
CB5476675
Summenformel:
C11H15N5O4
Molgewicht:
281.27
MOL-Datei:
2140-79-6.mol
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2'-O-Methyladenosine Eigenschaften

Schmelzpunkt:
200-202 C
Siedepunkt:
623.8±65.0 °C(Predicted)
Dichte
1.84±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Löslichkeit
DMSO (Slightly), Methanol (Slightly, Heated, Sonicated), Water (Slightly)
Aggregatzustand
Powder
pka
13.13±0.70(Predicted)
Farbe
White to Off-white
Wasserlöslichkeit
Soluble in water.
maximale Wellenlänge (λmax)
259nm(H2O)(lit.)
InChI
InChI=1S/C11H15N5O4/c1-19-8-7(18)5(2-17)20-11(8)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
InChIKey
FPUGCISOLXNPPC-YGHVBYMHSA-N
SMILES
OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)[C@H](OC)[C@@H]1O
CAS Datenbank
2140-79-6(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 26-36-24/25
WGK Germany  3
HS Code  29349990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

2'-O-Methyladenosine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

2'-O-Methyladenosine (Cordysinin B) is a member of the class of adenosines that is adenosine in which the hydroxy group at position 2' is replaced by a methoxy group. It has been isolated from the mycelia of Cordyceps sinensis. It has a role as a fungal metabolite. It is a member of adenosines and an ether. It derives from an adenosine. analogue with antiviral properties, starting material for 2'-O'-methyl nucleotides. Potential metabolite of 2'-O-Me-cAMP.

Chemische Eigenschaften

White Solid

Verwenden

2'-O-Methyladenosine is an analog of adenosine used to prepare nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.

Definition

2'-O-Methyladenosine is nucleoside modification in which a methyl group is added to the 2' hydroxyl of the ribose moiety of adenosine.

Allgemeine Beschreibung

The 2'-O-Methyladenosine (Am) was showed to be the first nucleotide adjacent to the N7-methylguanosine (m7G) cap and it can be further modified at the N6 position by methylation to generate N6,2’-O-dimethyladenosine (m6Am) (92% chance of being modified), where the structure of m7G5'ppp5'm6AmpNp comprises 20–30% of all the structures[1]. The 2'-O-methyladenosine (Am) modification displaying the lowest level in tumor tissues[2].

Biologische Aktivität

2'-O-Methyladenosine, a methylated adenine residue is found in urine of normals as well as in urine of adenosine deaminase (ADA) deficient patients. 2'-O-Methyladenosine exhibits unique hypotensive activities.

2'-O-Methyladenosine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

3'-O-Methyl-D-adenosine 6-Chloro-9-(3,5-di-O-acetyl-2-O-methyl-β-D-ribofuranosyl)-9H-purine TRIMETHYLSULFONIUM HYDROXIDE

Downstream Produkte

Adenosine, N-methyl-3'-O-methyl- (9CI) N(6),O(2)-Dimethyladenosine

2'-O-Methyladenosine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 253)Lieferanten
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2140-79-6()Verwandte Suche:

2-Amino-9-beta-D-ribofuranosyl-9H-purine-6-(1H)-one hydrate NUCLEOSIDE PHOSPHORYLASE BACTERIAL Cobamamid Deaminase, Adenosin- Adenosin Adenosin-3',5'-phosphatmonohydrat S-ADENOSYL-L-METHIONINE Adenin 5'-Guanylsure Adenine phosphate 3'-Amino-3'-desoxy-N,N-dimethyladenosin Vidarabin Diadeninsulfat Adenosine 5'-triphosphate disodium salt ADENOSINE 5'-TRIPHOSPHATASE 3-Methyl-3H-adenin 6-Chlor-9-ribofuranosyl-9H-purin Adeninhydrochlorid
  • 2'-O-Methyladdenosine
  • 2'-O-Methyl-D-adenosine
  • 5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol
  • 2'-O-METHYLADENOSINE
  • 2'-OMe-A
  • (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol
  • (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-methoxy-2-methylol-tetrahydrofuran-3-ol
  • (2R,3R,4R,5R)-5-(6-azanylpurin-9-yl)-2-(hydroxymethyl)-4-methoxy-oxolan-3-ol
  • 2'-OMe Adenosine
  • 2'-OMe-rA
  • 2'-O-Methyladenosine, 99.0%
  • 2'-O-Me-Ado
  • -O-Methyladenosine
  • 2-Amino-N6-(dimethylaminomethylidene)-N2-isobutyryl-2&rsquo
  • (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxy-tetrahydrofuran-3-ol
  • 2'-OMe-Ar
  • 2'-O-Methyladenosine>
  • Adenosine, 2'-O-methyl-
  • 2'-O-Methyladenosine USP/EP/BP
  • AMI
  • (2R,3R,4R,5R)-5-(6-AMino-9H-purin-9-yl)-2-(hydroxyMethyl)-4-Methoxytetrahydrofuran-3-ol
  • cordysinin B
  • 2’-O-Methyl adenosine,RNA modified nucleoside Am
  • RNA modified nucleoside Am
  • -O-Methyladenosine
  • OMe-rA
  • 2'-O-Methyladenosine
  • 2140-79-6
  • Nucleosides, Nucleotides, Oligonucleotides
  • Nucleoside Analogs
  • BioChemical
  • Biochemicals and Reagents
  • Biochemicals and Reagents
  • Nucleoside Analogs
  • Nucleosides, Nucleotides, Oligonucleotides
  • Bases & Related Reagents
  • Carbohydrates & Derivatives
  • Heterocycles
  • Nucleotides
  • Nucleosides
  • Modified（deoxy）nucleoside
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