Entacapone
|
|
|
- CAS-Nr.
- 130929-57-6
- Englisch Name:
- Entacapone
- Synonyma:
- (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide;Comtan;Comtes; OR-611;Comtess;HSDB8251;HSDB 8251;HSDB-8251;ENTACAPONE;E Entacapone
- CBNumber:
- CB5726435
- Summenformel:
- C14H15N3O5
- Molgewicht:
- 305.29
- MOL-Datei:
- 130929-57-6.mol
|
Entacapone Eigenschaften
- Schmelzpunkt:
- 162-1630C
- Siedepunkt:
- 526.6±50.0 °C(Predicted)
- Dichte
- 1.392±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: soluble20mg/mL, clear
- Aggregatzustand
- powder
- pka
- pKa ~4.5(at 25℃)
- Farbe
- white to light brown
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
- InChIKey
- JRURYQJSLYLRLN-BJMVGYQFSA-N
- CAS Datenbank
- 130929-57-6(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
|
| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
| P332+P313 |
Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P337+P313 |
Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
|
Entacapone Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Entacapone was introduced in Finland, Germany and Sweden as an
adjunctive treatment with L-dopa in Parkinson’s disease. Entacapone is the
second drug in its class to reach the market; it can be obtained by
basecatalyzed condensation of the corresponding benzaldehyde with a
cyanoacetamide. Entacapone is a highly selective and orally-active catechol-0-
methyltransferase (COMT) inhibitor ; by inhibiting metabolism of L-dopa when
given as an adjuvant in patients with Parkinson’s disease, Entacapone markedly
prolongs the effects of L-dopa and improves its bioavailability. Results from
clinical studies showed that 200mglday Entacapone coadministered with L-dopa
lowered the dose of the latter required to reduce fluctuations in motor
performance.
Chemische Eigenschaften
Yellow Crystalline Solid
Verwenden
(E)-Isomer of Entacapone polymorphic form A. Peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian
Definition
ChEBI: A monocarboxylic acid amide that is N,N-diethylprop-2-enamide in which the hydrogen at position 2 is substituted by a cyano group and the hydrogen at the 3E position is substituted by a 3,4-dihydroxy-5
nitrophenyl group.
Allgemeine Beschreibung
Entacapone, (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide (Comtan),is a nitrocatechol that is practically insoluble in water (pK
a＝4.50). Entacapone is rapidly absorbed after oral administrationand does not cross the BBB. Entacapone does not distributewidely into tissues because of its high plasma proteinbinding and it is completely metabolized before excretion.The main metabolic pathway is by isomerization to the cisisomerfollowed by direct glucuronidation of the parent andthe cis-isomer. The glucuronide conjugates are inactive.Entacapone is eliminated in the feces (90%) and urine (10%).Entacapone is indicated as an adjunct to levodopa/carbidopato treat patients with idiopathic PD who experience the signsand symptoms of end-of-dose wearing off.
Entacapone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Entacapone Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 468)Lieferanten
130929-57-6()Verwandte Suche:
- (E)-2-Cyano-3-(3，4-dihydroxy-5-nitrophenyl)-N，N-diethyl-2-pmpenamide
- Entacapone (150 mg)
- (2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enaMide
- 2-PropenaMide,2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)-
- Entacapone (isomer E)
- (E)-2-cyano-3-(5-(dihydroxyamino)-3,4-dioxocyclohexa-1,5-dienyl)-N,N-diethylacrylamide
- ENTACAPONE
- 2-cyano-3-(5-dihydroxyamino-3,4-dioxo-1-cyclohexa-1,5-dienyl)-n,n-diethyl-prop-2-enamide
- OR-611
- (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
- Comtes
- Comtess
- ENTACAPONE F·S
- Entacapone CRS
- Entacapone USP/EP/BP
- Entacapone Impurity 81
- Entacapone Impurity 82
- Entacapone Impurity 83
- E Entacapone
- Entacapone (OR611)
- EntacaponeQ: What is
Entacapone Q: What is the CAS Number of
Entacapone Q: What is the storage condition of
Entacapone Q: What are the applications of
Entacapone
- Entacapone (Y0001249)
- Entacapone (1235933)
- Comtan
- (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide
- Well he carpenters
- Entacapone (API)
- (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide[OR-611
- HSDB 8251
- HSDB8251
- HSDB-8251
- 130929-57-6
- 30929-57-6
- C14H15N4O4
- Histone Methyltransf
- Intermediates & Fine Chemicals
- Pharmaceuticals
