3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone

3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone Struktur
812647-88-4
CAS-Nr.
812647-88-4
Englisch Name:
3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone
Synonyma:
YM-08;3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone;4-Thiazolidinone, 3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-
CBNumber:
CB62750691
Summenformel:
C19H17N3OS2
Molgewicht:
367.49
MOL-Datei:
812647-88-4.mol

3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone Eigenschaften

storage temp. 
2-8°C
Aggregatzustand
powder
Farbe
yellow to orange

Sicherheit

WGK Germany  3

3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone Chemische Eigenschaften,Einsatz,Produktion Methoden

Biochem/physiol Actions

YM-08 is a Heat Shock Protein 70 (Hsp70) inhibitor that is blood-brain barrier permeable. YM-08 is a neutral derivative of the Hsp70 inhibitor MKT-077. MKT-077 reduces tau levels in cellular models, but it doesn′t penetrate the blood brain barrier. Although YM-08 was somewhat less effective than MKT-077 in anti-tau and anticancer assays, it selectively reduced pathogenic tau in brain slices, which MKT-077 did not. Furthermore,YM-08 was not retained in the kidney leading one to speculate that it would not have the nephrotoxicity that was a problem for MKT-077 in clinical trials.

3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 14)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52927 58
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51471 80
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822
czbjpharma@126.com China 18488 58
Suzhou Zhixin Biotechnology Co., Ltd. 0512-65118909 15162312715
sales@szzxbio.com China 2997 58

  • 3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone
  • YM-08
  • 4-Thiazolidinone, 3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-
  • 812647-88-4
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