12-Oxo-5-α-spirostan-3-β-ylacetat Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Hecogenin acetate is a steroid sapogenin and an acetylated form of hecogenin that has anthelmintic and antinociceptive properties. It reduces the percentage of mobile larvae in goat fecal cultures containing
Haemonchus, Oesophagostomum, and
Trichostrongylus nematodes (EC
50 = 0.49 mg/ml). Hecogenin acetate (5, 10, or 20 mg/kg, i.p.) inhibits development of mechanical hyperalgesia induced by carrageenan, TNF-α, dopamine , and prostaglandin E
2 (PGE
2; ) in mice. It also increases latency to tail withdrawal in the tail flick test and has no effect on motor performance in the rotarod test in mice when administered at a dose of 40 mg/kg.
Verwenden
Hecogenin Acetate, is a derivative of Hecogenin (H129945), which is a sapogenin present in the leaves of species from the Agave genus, possessing wide spectrum of pharmacology activities, such as having antinociceptive properties.
läuterung methode
Crystallise the acetate from MeOH. [Beilstein 19 IV 2583.]
12-Oxo-5-α-spirostan-3-β-ylacetat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
