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(+/-)-8-PRENYLNARINGENIN

(+/-)-8-PRENYLNARINGENIN Struktur
68682-02-0
CAS-Nr.
68682-02-0
Englisch Name:
(+/-)-8-PRENYLNARINGENIN
Synonyma:
rac 8-Prenylnaringenin;(+/-)-8-PRENYLNARINGENIN;Naringenin 8-Prenyl Racemate;2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-Methyl-2-buten-1-yl)-4H-1-benzopyran-4-one;(±)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-Methyl-2-butenyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-
CBNumber:
CB6504166
Summenformel:
C20H20O5
Molgewicht:
340.37
MOL-Datei:
68682-02-0.mol
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(+/-)-8-PRENYLNARINGENIN Eigenschaften

Schmelzpunkt:
183-184 °C
Siedepunkt:
597.6±50.0 °C(Predicted)
Dichte
1.314±0.06 g/cm3(Predicted)
storage temp. 
−20°C
Löslichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Light yellow powder
pka
7.70±0.40(Predicted)
Farbe
Off-White to Pale Yellow
Stabilität:
Light Sensitive

Sicherheit

S-Sätze: 22-24/25
WGK Germany  3

(+/-)-8-PRENYLNARINGENIN Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

(±)-8-Prenylnaringenin ((±)-8-PN) is a prenylflavonoid with potent estrogenic activity that can be isolated from hops. It inhibits both isoforms of the human estrogen receptor (ER; IC50s = 57 and 68 nM for ERα and ERβ, respectively). (±)-8-PN is effective in vivo, suppressing loss of bone mineral density in ovariectomized rats and blocking changes in tail skin temperature in a rat model of postmenopausal hot flashes.

Verwenden

8-Prenylnaringenin is a prenylflavonoid, a class on non-steroidal phytoestrogen that mimicks and/or modulating endogenous estrogens via estrogen receptor binding.

(+/-)-8-PRENYLNARINGENIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Licoflavone C

(+/-)-8-PRENYLNARINGENIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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  • (±)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-Methyl-2-butenyl)-4H-1-benzopyran-4-one
  • 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-Methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
  • rac 8-Prenylnaringenin
  • 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-
  • Naringenin 8-Prenyl Racemate
  • (+/-)-8-PRENYLNARINGENIN
  • 68682-02-0
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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