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2-IMINOTHIOLANE

2-IMINOTHIOLANE Struktur
4781-83-3
CAS-Nr.
4781-83-3
Englisch Name:
2-IMINOTHIOLANE
Synonyma:
2-IMINOTHIOLANE HYDROCHLORIDE;TRAUT'S REAGENT;Nsc340007;2-Iminothiolane ,98%;dihydrothiophen-2(3H)-iMine;2-IMINOTHIOLANE;thiolan-2-iMine;2-IMINOTHIOLANE HCL;IMinothiolane hydrochlorid;2-THIOLANIMINE HYDROCHLORIDE
CBNumber:
CB7373482
Summenformel:
C4H7NS.ClH
Molgewicht:
137.63
MOL-Datei:
4781-83-3.mol
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2-IMINOTHIOLANE Eigenschaften

Schmelzpunkt:
198-201 °C(lit.)
storage temp. 
2-8°C
Löslichkeit
H2O: 100 mg/mL
Aggregatzustand
powder
Farbe
White to Off-White
Wasserlöslichkeit
Freely soluble in water
BRN 
3620079
CAS Datenbank
4781-83-3(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
S-Sätze: 22-24/25
WGK Germany  3
F  1-3-10
HS Code  29349990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

2-IMINOTHIOLANE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

White Crystalline Solid

Verwenden

2-Iminothiolane hydrochloride is a valuable tool in studies of cellular organelles and oligomeric enzymes, using the techniques of protein-protein cross-linking. It may also be used to introduce reactive sulfhydryl groups into proteins for subsequent reaction with alkylating agents or heavy metal compounds.

Allgemeine Beschreibung

2-Iminothiolane hydrochloride (2-IT.HCl), a protein modification reagent, is commonly employed to attach thiol groups to proteins and peptides. Raman spectroscopic analysis of hair keratin fibers modified with 2-IT.HCl showed the formation of new disulfide groups.

läuterung methode

Recrystallise the hydrochloride from MeOH/Et2O (m 187-192o) or (MeOH/Me2CO), but after sublimation at ~180o/0.2mm the melting point rises to 202-203o. It has 1HNMR with 2.27 (2H, t), 3.25 (2H, t) and 3.52 (2H, t) in (CD3)2SO. [King et al. Biochemistry 17 1499 1978.] The free base is purifed by vacuum distillation (b 71-72o/6mm) with IR (film) with 1700 (C=N)cm-1 and 1HNMR (CDCl3) with at 3.58 (2H, t) and max 2.10-2.8 (4H, m). The free base is stable on storage but slowly hydrolyses in aqueous solutions with half-lives at 25o of 390hours at pH 9.1, 210hours at pH 10 and 18hours at pH 11. [Traut et al. Biochemistry 12 3266 1973, Biochemistry 17 399 1978, Alagon & King Biochemistry 19 4343 1980, Beilstein 17/9 V 12.]

2-IMINOTHIOLANE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2-IMINOTHIOLANE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 141)Lieferanten
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4781-83-3()Verwandte Suche:

S-(2-((2,5-Dioxo-1-pyrrolidinyl)-oxy)oxoethyl)ethanthionsäureester
  • 2-Iminothiolane hydrochloride,2-Thiolanimine hydrochloride, 2IT, Dihydro-2(3H)-thiophenimine hydrochloride, Traut’s reagent
  • thiolan-2-iMine
  • 2(3H)-ThiopheniMine,dihydro-, hydrochloride (1:1)
  • 2-Iminothiolane hydrochloride >=98% (TLC), powder
  • IMinothiolane hydrochlorid
  • Traut's reagent,2-Iminothiolane hydrochloride
  • Dihydrothiophen-2(3H)-imine hydrochloride
  • 2-Iminothiolane hydrochloride≥ 98% (HPLC)
  • 2-THIOLANIMINE HYDROCHLORIDE
  • 2-IMINOTHIOLANE
  • 2-IMINOTHIOLANE HCL
  • METHYL 4-MERCAPTOBUTYRIMIDATE HYDROCHLORIDE
  • DIHYDRO-2(3H)-THIOPHENIMINE HYDROCHLORIDE
  • Methyl-4-mercaptobutyrimidate hydrochloride 2-Iminothiolane hydrochloride
  • 2(3H)-Thiophenimine, dihydro-, hydrochloride
  • 2-Thiolanimine hydrochloride, 2IT, Dihydro-2(3H)-thiophenimine hydrochloride, Trauts reagent
  • 2-Furancarboxyaldehyde, Reagent
  • 2(3H)-Thiophenimine, dihydro-, dihydrochloride
  • thiolan-2-imine hydrochloride
  • TRAUT'S REAGENT
  • 2-IMINOTHIOLANE HYDROCHLORIDE
  • dihydrothiophen-2(3H)-iMine
  • 2-Iminothiolane ,98%
  • Nsc340007
  • 2-Aminothiolidine hydrochloride
  • 4781-83-3
  • C4H7N1S1
  • C4H7NSHCl
  • C4H8ClNS
  • BioChemical
  • Reagents for lysine modification
  • Protein Modification
  • Proteomics and Protein Expression
  • Proteomics
  • Specific Amino Acid Modification
  • Protein Modification Reagents
  • MTS and Sulfhydryl Active Reagents
  • MTS & Sulfhydryl Active Reagents
  • Sulfur & Selenium Compounds
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