ZorubicinHydrochloride

ZorubicinHydrochloride Struktur
CAS-Nr.
Englisch Name:
ZorubicinHydrochloride
Synonyma:
ZorubicinHydrochloride
CBNumber:
CB81021084
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

ZorubicinHydrochloride Eigenschaften

Schmelzpunkt:
>203°C (dec.)
storage temp. 
Amber Vial, -20°C Freezer, Under inert atmosphere
Löslichkeit
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Aggregatzustand
Solid
Farbe
Orange to Dark Red
Stabilität:
Light Sensitive

Sicherheit

ZorubicinHydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Zorubicin Hydrochloride,ZYF Pharm Chemical

Manufacturing Process

9.024 g daunorubicin-hydrochloride (its preparation and physicochemical properties have been described in British Patent Specification No 985 598) was dissolved in 800 ml ethanol and mixed with 2.5 ml acetic acid and 2.162 g benzoyl hydrazide and heated for 24 hours at 60°C. On cooling the obtained precipitate was filtered off, washed with 100 ml of ethanol and dried in vacuum at 20°C. It was dissolved in water and small quantity of insoluble product was filtered off, the filtrate was lyophilized. (1-(4-((3-Amino-2,3,6- trideoxy-α,L-lyxohexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12- trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)ethylidene)hydrazide dihydrochloride (zorubicin) was obtained as red-orange crystalline powder; [α] D 20 = -50° (c=0.2 in water). The compound may be employed in the form of different non-toxic salts such as benzoates, fumarates, maleates, tartrates and so on. The best among these compounds proves to be daunorubicin benzoylhydrazone (rubidazone), which is less cardiotoxic (French Pat. No. 1,578,722 published in 1967, Class CO7d).

Therapeutic Function

Antineoplastic, Antileukemic

ZorubicinHydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


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