IWR-1-endo
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- CAS-Nr.
- 1127442-82-3
- Englisch Name:
- IWR-1-endo
- Synonyma:
- IWR-1;CS-624;CS-1858;IWR-1-endo;endo-IWR 1;IWR-1-endo, >=98%;IWR-1(IWR-1-endo);IWR-1-endo USP/EP/BP;Wnt Antagonist I, IWR-1-endo;IWR-1-endo - IWR-1 | endo-IWR-1
- CBNumber:
- CB82518787
- Summenformel:
- C25H19N3O3
- Molgewicht:
- 409.44
- MOL-Datei:
- 1127442-82-3.mol
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IWR-1-endo Eigenschaften
- alpha
- -3.0～+3.0°(20℃/D)(c=0.1,CH3CN)
- Siedepunkt:
- 643.9±55.0 °C(Predicted)
- Dichte
- 1.425±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- Löslichkeit
- DMSO: soluble5mg/mL, clear
- pka
- 11.88±0.43(Predicted)
- Aggregatzustand
- Liquid
- Farbe
- white to beige
- Stabilität:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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IWR-1-endo Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
IWR-1-endo act as inhibitors of Wnt response. It appear that IWR compounds induce stabilization of Axin proteins via a direct interaction, which is a part of the b-catenin destruction complex (consists of Apc, Axin, Ck1 and Gsk3b). Such compounds may be used in the treatment of Wnt protein signaling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosi s.
Allgemeine Beschreibung
A cell-permeable
p-imidobenzamidoquinoline,
endo-diastereomer that is shown to inhibit the activity of TNKS1/PARP5a and TNKS2/PARP5b in
in vitro auto-PARsylation assays (IC
50 = 131 and 56 nM, respectively) and effectively suppress Wnt-stimulated transcription activity in L-Wnt-STF-based reporter assays (IC
50 = 180 nM), while exhibiting little activity against PARP1 or PARP2 (IC
50 >18.75 μM). Although both IWR-1-
endo and XAV939 (Tankyrase1/2 Inhibitor;
>Cat. No. 575545) act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both
in vitro and
in vivo, IWR-1-
endo exerts its effect via interaction with Axin, while XAV939 binds TNKS directly.
Biochem/physiol Actions
Cell permeable: yes
IWR-1-endo Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
IWR-1-endo Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 132)Lieferanten
1127442-82-3()Verwandte Suche:
- [(3aR*,4S*,7R*,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
- Benzamide, 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinyl-, rel-
- endo-IWR 1
- IWR-1-endo
- rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-Methano-2H-isoindol-2-yl]-N-8-quinolinylbenzaMide
- rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide IWR-1-endo
- IWR-1-endo, >=98%
- ENDO-IWR 1;IWR-1-ENDO;IWR1;IWR 1
- 4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-N-8-quinolinyl-Benzamide (IWR-1)
- CS-1858
- IWR-1(IWR-1-endo)
- IWR-1-endo - IWR-1 | endo-IWR-1
- CS-624
- Wnt Antagonist I, IWR-1-endo
- IWR-1-endo USP/EP/BP
- rel-4-((3aR,4S,7R,7aS)-1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(quinolin-8-yl)benzamide
- IWR-1
- 1127442-82-3
- Chiral Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Inhibitors
