Morinidazole Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Morinidazole, discovered and developed by Jiangsu Hansoh Pharmaceutical, was approved by the CFDA in February 2014. Morinidazole is a novel third generation 5-nitroimidazoleclass antimicrobial agent indicated for the treatment of amoebiasis and anaerobic bacterial infections including appendicitis and pelvic inflammatory disease. 5-Nitroimidazole antimicrobial drugs act via nitroreduction of the molecules in the pathogens; as an analog of metronidazole, morinidazole exhibits greater antiparasitic potency against Trichomonas vaginalis and amoebic protozoa, and relatively weaker toxicity in vitro and in preclinical studies compared with metronidazole.
Synthese
The strategy to prepare morinidazole, which exists as a racemate,
overlaps with that of ornidazole. Commercially available epichlorohydrin (176) was
reacted with commercial 2-methyl-5-nitro-1H-imidazole (175) to
provide ornidazole 177 in 51% yield. Next, epoxide 178 was
obtained in 84% through the treatment of ornidazole 177 with
TBAF in aqueous sodium hydroxide. Subsequently, the ring of
epoxide 178 was opened with the treatment of morpholine (179)
to afford morinidazole (XX) in 75% yield.
Morinidazole Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
