D-GALACTOSAMINE

D-GALACTOSAMINE Struktur
7535-00-4
CAS-Nr.
7535-00-4
Englisch Name:
D-GALACTOSAMINE
Synonyma:
C02262;D-Chondrosamine;D-GALACTOSAMINE;d-2-amino-2-deoxygalactose;D-Galactose, 2-amino-2-deoxy-;(2R,3R,4R,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal
CBNumber:
CB8389318
Summenformel:
C6H13NO5
Molgewicht:
179.17
MOL-Datei:
7535-00-4.mol

D-GALACTOSAMINE Eigenschaften

Schmelzpunkt:
185 °C
Siedepunkt:
532.5±50.0 °C(Predicted)
Dichte
1.491±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
11.21±0.45(Predicted)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

D-GALACTOSAMINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Galactosamine is a model hepatotoxicant, induces hepatitis characterized by neutrophilic infiltration, and kills the animal by fulminant hepatic failure. Galactosamine, an amino derivative of sugar galactose, has been used as a model hepatotoxicant since the first reports of hepatotoxicity in late 1970s by Keppler and associates. Galactosamine-induced hepatitis has been a model of choice to study various aspects of liver disease, including mechanisms of toxicant-induced apoptosis and necrosis, liver tissue repair, neutrophil infiltration and transmigration, and the role of endotoxin or lipopolysaccharide (LPS) in initiating liver injury.
Humans and animals synthesize galactosamine in the body. Galactosamine (a type of hexosamine) is formed when an amino group replaces one of the hydroxy groups of a sixcarbon sugar, or hexose. The human body utilizes uridine diphosphate (UDP)-N-acetyl-D-glucosamine or glucosamine as a precursor to synthesize this compound, and is most often found in the form N-acetyl-D-galactosamine (often referred to as N-acetylgalactosamine). Most importantly, galactosamine is a constituent of hyaluronic acid, a powerful water-binding agent. Many different types of tissues in human body contain hyaluronic acid, which acts as a lubricating agent in the synovial fluid of joints and in connective tissues. Hyaluronic acid also acts as a lubricating agent in the vitreous humor of the eyeball. Hyaluronic acid has considerable medicinal value; it is often used in wound healing, burn dressings, osteoarthritis treatment, cataract or corneal transplantation surgery, and various types of plastic surgeries.

Definition

ChEBI: The pyranose form of D-galactosamine.

Toxicity evaluation

Galactosamine induces liver injury by interfering with the uridine pool in the cell, which is essential for RNA and protein synthesis. Galactosamine ismetabolized via the Leloir pathway of galactose metabolism, which leads to the generation of uridine derivatives of galactosamine. The two enzymes of the Leloir pathway, galactokinase and UDP-galactose uridyltransferase, convert galactosamine into galactosamine-1-phosphate and UDP-galactosamine, respectively,due to their lowsubstrate specificity.UDPgalactosamine blocks the final enzyme in Leloir pathway, the UDP-galactose-40 epimerase, resulting in the accumulation of UDP-galactosamine in the cells. This results in the depletion of uridine triphosphate (UTP), UDP, uridine monophosphate (UMP), and the sugar derivative of uridine such as UDP-glucose and UDP-galactose essential for RNA and protein synthesis. Orotate, a precursor of the hexosamine biosynthesis pathway, has been used as an antidote to galactosamine toxicity.

D-GALACTOSAMINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


D-GALACTOSAMINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 26)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Jinan Carbotang Biotech Co.,Ltd.
+8615866703830
figo.gao@foxmail.com China 7019 58
Wuhan Fortuna Chemical Co., Ltd
+86-27-59207850 +86-13986145403
info@fortunachem.com China 5989 58
Aikon International Limited 025-66113011 13155353615
qzhang@aikonchem.com China 15396 58
Jinan Kabotang Biological Technology Co.,Ltd. 0531-61320525 15866703830
495745175@qq.com China 6890 58
Shanghai Haohong Pharmaceutical Co., Ltd. 400-400-8210725 4008210725
malulu@leyan.com China 55023 58
He' nan syndicate biology science and technology co., ltd 17513242016
1576861551@qq.com China 1266 58
Hubei Guangao Biotechnology Co., Ltd 027-027-59223056 18162699093
1208480011@qq.com China 9951 58
Hubei Wande Chemical Co., Ltd 027-59210159 15377098680
1148280011@qq.com China 9994 58
Wuhan Fortuna Chemical Co., Ltd 027-027-59207852 13308628970
buy@fortunachem.com China 2640 58

7535-00-4()Verwandte Suche:


  • d-2-amino-2-deoxygalactose
  • D-GALACTOSAMINE
  • C02262
  • D-Chondrosamine
  • (2R,3R,4R,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal
  • D-Galactose, 2-amino-2-deoxy-
  • 7535-00-4
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