Tienilinsure
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- CAS-Nr.
- 40180-04-9
- Bezeichnung:
- Tienilinsure
- Englisch Name:
- TICRYNAFEN
- Synonyma:
- Tienilic;Tienilic Acid - Ticrynafan;ce3624;ticrex;fr3068;anp3624;ANP 362;skf62698;selacryn;diflurex
- CBNumber:
- CB8500854
- Summenformel:
- C13H8Cl2O4S
- Molgewicht:
- 331.17
- MOL-Datei:
- 40180-04-9.mol
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Tienilinsure Eigenschaften
- Schmelzpunkt:
- 148-149oC
- Siedepunkt:
- 534.6±50.0 °C(Predicted)
- Dichte
- 1.532
- storage temp.
- -20°C
- Löslichkeit
- DMSO: soluble5mg/mL (clear solution)
- Aggregatzustand
- powder
- pka
- 2.79±0.10(Predicted)
- Farbe
- white to beige
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
22 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
AG9300000 |
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| Toxizität |
LD50 in mice (mg/kg): 225 i.v., 1275 orally (US 3758506) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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Tienilinsure Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Pale Beige Solid
Verwenden
A heterocycloc derivative of phenoxyacetic Acid. Uses as a diuretic, uricosuric, anhtihypertensive
Definition
ChEBI: An aromatic ketone that is 2,3-dichlorophenoxyacetic acid in which the hydrogen at position 4 on the benzene ring is replaced by a thiophenecarbonyl group. A loop diuretic used to treat hypertension, it was withdrawn from the market in 1982 due to links wi
h hepatitis.
Weltgesundheitsorganisation (WHO)
Tienilic acid, a diuretic agent with uricosuric and antihypertensive
activity, was introduced in 1976. By 1979 its use had been associated with cases of
hepatic toxicity, some of which were fatal, which led to the withdrawal of the drug
in most countries in which it was marketed. In France, however, precautions
regarding the use of tienilic acid were issued by the Pharmacovigilance
Commission and the drug remained available for another decade. In 1991, it was
eventually also withdrawn there since cases of hepatitis, some of which were
fulminant, had continued to occur.
Tienilinsure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Tienilinsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 93)Lieferanten
40180-04-9(Tienilinsure)Verwandte Suche:
- ce3624
- diflurex
- fr3068
- selacryn
- skf62698
- thienylicacid
- ticrex
- (2,3-dichloro-4-(2-thenoyl)phenoxy)aceticacid
- (2,3-dichloro-4-(2-thienylcarbonyl)phenoxy)-aceticaci
- (2,3-dichloro-4-(2-thienylcarbonyl)phenoxy)aceticacid
- (2,3-dichloro-4-(2-thiophenecarbonyl)phenoxy)aceticacid
- 4-(2-theonyl)-2,3-dichlorphenoxyessigsaeure
- 4-(2-thienylketo)-2,3-dichlorophenoxyaceticacid
- anp3624
- tienilicacid
- [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]aceticAcid,TienilicAcid,ThienylicAcid,ANP-3624,CE-3624,SKF-62698,Dif
- [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]acetic Acid, Tienilic Acid, Thienylic Acid, ANP-3624, CE-3624, SKF-62698, Diflurex, Selacryn
- TIENILIC ACID(TICRYNAFEN)
- 4-(2-Thienylcarbonyl)-2,3-dichlorophenoxyacetic acid
- Difluorex
- Tienylic acid
- 2-[2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]acetic Acid
- 4-(2-Thenoyl)-2,3-dichlorophenoxyacetic Acid
- 2-{2,3-dichloro-4-[(thiophen-2-yl)carbonyl]phenoxy}acetic acid
- 2-(2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid
- Acetic acid, 2-[2,3-dichloro-4-(2-thienylcarbonyl)phenoxy]-
- ANP 362
- Tienilic Acid Solution, 100ppm
- TICRYNAFEN USP/EP/BP
- TICRYNAFEN ISO 9001：2015 REACH
- Tienilic
- Tienilic Acid - Ticrynafan
- Ticrynafen, Tienilic acid
- ANP 3624,Tienilic Acid,Inhibitor,Uricosuric,Diuretic,inhibit,Hepatotoxicity,ANP3624,Ticrynafen,ANP-3624
- ienilicaci
- Tinic acid（Axitinib Impurity 18）
- 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid（Tienilic Acid）
- 40180-04-9
- Aromatics
- Sulfur & Selenium Compounds
- Heterocyclic Compounds
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
