Eicosanoids

Eicosanoids Struktur
CAS-Nr.
Englisch Name:
Eicosanoids
Synonyma:
Eicosanoids
CBNumber:
CB91331182
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

Eicosanoids Eigenschaften

Sicherheit

Eicosanoids Chemische Eigenschaften,Einsatz,Produktion Methoden

Indications

The eicosanoids, so called because of their derivation from a 20-carbon unsaturated fatty acid, arachidonic acid (eicosatetraenoic acid), are obtained from membrane phospholipids and synthesized de novo at the time of cellular stimulation. Arachidonic acid is cleaved from membrane-bound phosphatidylcholine by the enzyme phospholipase A2. Alternatively, arachidonic acid may be derived by the sequential actions of phospholipase C and diacylglyceryl lipase. Arachidonic acid can then follow either of two enzymatic pathways that result in the production of inflammatory mediators.
The production of inflammatory eicosanoids is an important target of many anti-inflammatory drugs. In addition, the side effects of these drugs frequently result from their inhibition of eicosanoid production. A number of eicosanoids are used as therapeutic agents. In infants with congenital heart anomalies, a patent ductus arteriosus can be temporarily maintained by the PGE1 analogue alprostadil (Prostin VR Pediatric) until surgical correction can be performed.

Clinical Use

A number of eicosanoids are used as therapeutic agents. In infants with congenital heart anomalies, a patent ductus arteriosus can be temporarily maintained by the PGE1 analogue alprostadil (Prostin VR Pediatric) until surgical correction can be performed. In patients undergoing treatment with nonsteroidal antiinflammatory drugs, the PGE1 analogue misoprostol (Cytotec) is often used to decrease gastric acid secretion, thereby inhibiting the ulceration caused by these agents. Misoprostol is also used in several non- FDA–approved applications, including the induction of labor by enhancing cervical ripening, and the induction of abortion in combination with mifepristone (RU-486). These uses of misoprostol are associated with an increased risk of uterine rupture or perforation. Dinoprostone (Prostin E2), a synthetic PGE2, causes uterine contraction and is used clinically to induce abortion during the second trimester and to empty the uterus following fetal death, missed abortion, or benign hydatidiform mole. Carboprost (Hemabate) is a PGF2 analogue that can be used to terminate pregnancy or to control refractory postpartum bleeding by stimulating uterine contraction. Primary pulmonary hypertension can be treated by the synthetic PGI epoprostenol (Flolan). Elevated intraocular pressure may be treated with latanoprost (Xalatan), an analogue of PGF2. Zafirlukast (Accolate) is an oral leukotriene receptor antagonist for control of the inflammatory process of asthma. Zileuton (Zyflo) inhibits the first enzyme in the lipoxygenase pathway and is used for the treatment of asthma.

Eicosanoids Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Eicosanoids Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 1)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Triveni chemicals --
sales@trivenichemical.com India 6093 58

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