(S)-1-Boc-2-(Hydroxymethyl)piperazine

1030377-21-9

CAS-Nr.: 1030377-21-9

Englisch Name:: (S)-1-Boc-2-(Hydroxymethyl)piperazine

Synonyma:: (S)-1-Boc-2-(hyroxyMethyl)piperazine;(S)-1-N-BOC-2-HYDROXYMETHYLPIPERAZINE;(S)-N1-BOC-2-Hydroxymethyl-piperazine;(2S)-2-(Hydroxymethyl)piperazine, N1-BOC protected;(S)-tert-butyl 2-(hydroxyMethyl)piperazin-1-carboxylate;(S)-tert-butyl 2-(hydroxyMethyl)piperazine-1-carboxylate;tert-butyl (S)-2-(hydroxymethyl)piperazine-1-carboxylate;tert-butyl (2S)-2-(hydroxymethyl)piperazine-1-carboxylate;1,1-Dimethylethyl (2S)-2-(hydroxymethyl)-1-piperazinecarboxylate;(S)-2-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

CBNumber:: CB9233339

Summenformel:: C10H20N2O3

Molgewicht:: 216.28

MOL-Datei:: Mol file

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 106

(S)-1-Boc-2-(Hydroxymethyl)piperazine Eigenschaften

Siedepunkt:: 324℃

Dichte: 1.085

Flammpunkt:: 150℃

storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C

pka: 14.97±0.10(Predicted)

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

HS Code	2933599590

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P302+P352, P321,P332+P313, P362
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P305+P351+P338,P337+P313P
H335	Kann die Atemwege reizen.	Spezifische Zielorgan-Toxizität (einmalige Exposition)	Kategorie 3 (Atemwegsreizung)	Warnung	src="/GHS07.jpg" width="20" height="20" />

Sicherheit

P261	Einatmen von Staub vermeiden.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

(S)-1-Boc-2-(Hydroxymethyl)piperazine Chemische Eigenschaften,Einsatz,Produktion Methoden

Reaktionen

(S)-1-Boc-2-(Hydroxymethyl)piperazine reacts with 1,2-difluoro-4-nitrobenzene to synthesize tert-butyl (S)-4-(2-fluoro-4-nitrophenyl)-2-(hydroxymethyl)piperazine-1-carboxylate. This compound serves as a crucial intermediate in the preparation of the Wee-1 kinase activity inhibitor.

Synthese

To a solution of (S)-4-benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate (1.5 g, 4.28 mmol) in MeOH (20 mL), 10 % Pd/C (150 mg) was added. The mixture was stirred at room temperature for 3 hours under H2. Afterwards, the solid was removed by filtration and the filtrate was concentrated to yield (S)-1-Boc-2-(Hydroxymethyl)piperazine (850 mg, 3.93 mmol, 91.82 percent) as a white solid.
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(S)-1-Boc-2-(Hydroxymethyl)piperazine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

1,4-Piperazinedicarboxylic acid, 2-(hydroxymethyl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester, (2S)-

Downstream Produkte

(S)-1-Boc-2-(Hydroxymethyl)piperazine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 106)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shanghai Boc Chemical Co., Ltd.	021-34975602; +8618721111801	shangli@bocchem.com	China	138	58
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	7019	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21149	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58

(2S)-2-(Hydroxymethyl)piperazine, N1-BOC protected
tert-Butyl (2S)-2-(hydroxymethyl)piperazine-1-carboxylate, (2S)-1-(tert-Butoxycarbonyl)-2-(hydroxymethyl)piperazine
tert-butyl (S)-2-(hydroxymethyl)piperazine-1-carboxylate
tert-butyl (2S)-2-(hydroxymethyl)piperazine-1-carboxylate
(S)-2-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
(S)-1-N-BOC-2-HYDROXYMETHYLPIPERAZINE
1-PIPERAZINECARBOXYLIC ACID, 2-(HYDROXYMETHYL)-, 1,1-DIMETHYLETHYL ESTER, (2S)-
(S)-tert-butyl 2-(hydroxyMethyl)piperazin-1-carboxylate
(S)-tert-butyl 2-(hydroxyMethyl)piperazine-1-carboxylate
(S)-1-Boc-2-(hyroxyMethyl)piperazine
1,1-Dimethylethyl (2S)-2-(hydroxymethyl)-1-piperazinecarboxylate
(2S)-2-(hydroxymethyl)-1-Piperazinecarboxylic acid tert-butyl ester
(S)-N1-BOC-2-Hydroxymethyl-piperazine
1030377-21-9