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ABT-639

ABT-639 Struktur
1235560-28-7
CAS-Nr.
1235560-28-7
Englisch Name:
ABT-639
Synonyma:
ABT-639;ABT-693;CS-2286;ABT-639 (ABT639;ABT-639, CID 46851313;Calcium Channel,Ca channels,Ca2+ channels,inhibit,Inhibitor,ABT639,ABT-639;(R)-4-chloro-2-fluoro-N-(2-fluorophenyl)-5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide;4-CHLORO-2-FLURO-N-(2-FLUOROPHENYL)-5-[(8AR)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-2(1H)-YLCARBONYL]BENZENESULFONAMIDE;4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide;Benzenesulfonamide, 4-chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]-
CBNumber:
CB93121075
Summenformel:
C20H20ClF2N3O3S
Molgewicht:
455.91
MOL-Datei:
1235560-28-7.mol
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ABT-639 Eigenschaften

Siedepunkt:
612.2±65.0 °C(Predicted)
Dichte
1.51±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
Löslichkeit
DMSO:9.71(Max Conc. mg/mL);21.3(Max Conc. mM)
DMF:14.0(Max Conc. mg/mL);30.71(Max Conc. mM)
DMF:PBS (pH 7.2) (1:20):0.04(Max Conc. mg/mL);0.09(Max Conc. mM)
Ethanol:0.5(Max Conc. mg/mL);1.1(Max Conc. mM)
Aggregatzustand
A solid
pka
6.80±0.10(Predicted)

Sicherheit

ABT-639 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

ABT-639 is a selective T-type calcium channel blocker with efficacy in a wide range of preclinical models of nociceptive and neuropathic pain.ABT-639 produces robust antinociceptive activity in experimental pain models at doses that do not significantly alter psychomotor or hemodynamic function in the rat.

Einzelnachweise

Zhang, Q., et al. "Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639."Acs Medicinal Chemistry Letters6.6(2015):150429091057009.
Serra, J, et al. "Effects of a T-type calcium channel blocker, ABT-639, on spontaneous activity in C-nociceptors in patients with painful diabetic neuropathy: a randomized controlled trial. " Pain 156.11(2015):2175.
http://www.medkoo.com/products/6989

ABT-639 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ABT-639 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 61)Lieferanten
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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career henan chemical co 		+86-0371-86658258 15093356674;
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ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8474 58
Aladdin Scientific 		+1-833-552-7181
sales@aladdinsci.com United States 57511 58
  • ABT-639
  • 4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide
  • 4-CHLORO-2-FLURO-N-(2-FLUOROPHENYL)-5-[(8AR)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-2(1H)-YLCARBONYL]BENZENESULFONAMIDE
  • ABT-639, CID 46851313
  • (R)-4-chloro-2-fluoro-N-(2-fluorophenyl)-5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide
  • ABT-639 (ABT639
  • CS-2286
  • ABT-693
  • Benzenesulfonamide, 4-chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]-
  • Calcium Channel,Ca channels,Ca2+ channels,inhibit,Inhibitor,ABT639,ABT-639
  • 1235560-28-7
  • C20H20ClF2N3O3S
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