Sorbic acid

Sorbic acid Struktur
22500-92-1
CAS-Nr.
22500-92-1
Englisch Name:
Sorbic acid
Synonyma:
CBNumber:
CB9954577
Summenformel:
C6H8O2
Molgewicht:
0
MOL-Datei:
22500-92-1.mol

Sorbic acid Eigenschaften

Löslichkeit
Slightly soluble in water, freely soluble in ethanol (96 per cent).
Geruch (Odor)
characteristic
InChI
InChI=1S/C6H8O2/c1-2-3-4-5-6(7)8/h2-5H,1H3,(H,7,8)/b3-2+,5-4+
InChIKey
WSWCOQWTEOXDQX-MQQKCMAXSA-N
SMILES
C(O)(=O)/C=C/C=C/C
LogP
1.268 (est)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P321 Besondere Behandlung
P332+P313 Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P362 Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen.

Sorbic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Sorbic acid is a tasteless, white to yellow-white crystalline powder with a faint characteristic odor.

Verwenden

Pharmaceutic aid (antimicrobial agent).

Definition

ChEBI: A hexadienoic acid with double bonds at C-2 and C-4; it has four geometrical isomers, of which the trans,trans-form is naturally occurring.

Vorbereitung Methode

Naturally occurring sorbic acid may be extracted as the lactone (parasorbic acid) from the berries of the mountain ash Sorbus aucuparia L. (Fam. Rosaceae). Synthetically, sorbic acid may be prepared by the condensation of crotonaldehyde and ketene in the presence of boron trifluoride; by the condensation of crotonaldehyde and malonic acid in pyridine solution; or from 1,1,3,5- tetraalkoxyhexane. Fermentation of sorbaldehyde or sorbitol with bacteria in a culture medium has also been used.

Pharmazeutische Anwendungen

Sorbic acid is an antimicrobial preservative with antibacterial and antifungal properties used in pharmaceuticals, foods, enteral preparations, and cosmetics. Generally, it is used at concentrations of 0.05–0.2% in oral and topical pharmaceutical formulations, especially those containing nonionic surfactants. Sorbic acid is also used with proteins, enzymes, gelatin, and vegetable gums. It has been shown to be an effective preservative for promethazine hydrochloride solutions in a concentration of 1 g/L.
Sorbic acid has limited stability and activity against bacteria and is thus frequently used in combination with other antimicrobial preservatives or glycols, when synergistic effects appear to occur.

Sicherheit(Safety)

Sorbic acid is used as an antimicrobial preservative in oral and topical pharmaceutical formulations and is generally regarded as a nontoxic material. However, adverse reactions to sorbic acid and potassium sorbate, including irritant skin reactions and allergic hypersensitivity skin reactions (which are less frequent), have been reported.
Other adverse reactions that have been reported include exfoliative dermatitis due to ointments that contain sorbic acid, and allergic conjunctivitis caused by contact lens solutions preserved with sorbic acid.
No adverse reactions have been described after systemic administration of sorbic acid, and it has been reported that it can be ingested safely by patients who are allergic to sorbic acid. However, perioral contact urticaria has been reported.
The WHO has set an estimated total acceptable daily intake for sorbic acid, calcium sorbate, potassium sorbate, and sodium sorbate, expressed as sorbic acid, at up to 25 mg/kg bodyweight. Animal toxicological studies have shown no mammalian carcinogenicity or teratogenicity for sorbic acid consumed at up to 10% of the diet.
LD50 (mouse, IP): 2.82 g/kg
LD50 (mouse, oral): 3.20 g/kg
LD50 (mouse, SC): 2.82 g/kg
LD50 (rat, oral): 7.36 g/kg

Lager

Sorbic acid is sensitive to oxidation, particularly in the presence of light; oxidation occurs more readily in aqueous solution than in the solid form. Sorbic acid may be stabilized by phenolic antioxidants such as 0.02% propyl gallate.
Sorbic acid is combustible when exposed to heat or flame. When heated to decomposition, it emits acrid smoke and irritating fumes. The bulk material should be stored in a well-closed container, protected from light, at a temperature not exceeding 40℃.

Inkompatibilitäten

Sorbic acid is incompatible with bases, oxidizing agents, and reducing agents. Some loss of antimicrobial activity occurs in the presence of nonionic surfactants and plastics. Oxidation is catalyzed by heavy-metal salts. Sorbic acid will also react with sulfur-containing amino acids, although this can be prevented by the addition of ascorbic acid, propyl gallate, or butylhydroxytoluene.
When stored in glass containers, the solution becomes very pH sensitive; therefore, preparations using sorbic acid as a preservative should be tested for their microbial purity after prolonged periods of storage.
Aqueous solutions of sorbic acid without the addition of antioxidants are rapidly decomposed when stored in polypropylene, polyvinylchloride, and polyethylene containers.

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (ophthalmic solutions; oral capsules, solutions, syrups, tablets; topical and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Sorbic acid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Sorbic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 15)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 24099 58
Chongqing Chuandong Chemical (Group) Co. Ltd.
+86-13637972665 +86-13637972665
wxc@cd1958.com China 81 58
Beijing Ouhe Technology Co., Ltd 010-82967028 13552068683
2355560935@qq.com China 12439 60
shanghai science Bio-Pharmceutical.co,ltd. 021-021-57872719 13761402923
245662540@qq.com China 309 60
Nanjing chemical reagent co. LTD 025-025-58369808 17895012682
1848231502@qq.com China 3499 58
Hubei Xinhe Chemical Industry Co.,ltd. 027-83258456 15392830626
linkworld02@163.com China 206 58
Zhengzhou Yuhe Food Additive Co. LTD 0371-56060979 13838386843
2922109373@qq.com China 507 58
Shandong Aicai Biotechnology Co. , Ltd. 135-37016375 13573016375
3358761976@qq.com China 511 58
Nantong Zhonghe Chemical New Materials Co., Ltd 13003551299 13003551299
2369399482@qq.com China 7567 58
Xi'an Jinxiang Pharmaceutical Accessories Co., Ltd. 029-19991803015 19991803015
1309520151@qq.com China 221 58
Copyright 2019 © ChemicalBook. All rights reserved