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ChemicalBook >> CAS DataBase List >>1H-Pyrazole-5-carboxamide, 4-amino-1-[3-chloro-4-(2-pyridinylmethoxy)phenyl]-3-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-

1H-Pyrazole-5-carboxamide, 4-amino-1-[3-chloro-4-(2-pyridinylmethoxy)phenyl]-3-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-

1H-Pyrazole-5-carboxamide, 4-amino-1-[3-chloro-4-(2-pyridinylmethoxy)phenyl]-3-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]- Structure
1H-Pyrazole-5-carboxamide, 4-amino-1-[3-chloro-4-(2-pyridinylmethoxy)phenyl]-3-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]- structure
CAS No.
2711105-48-3
Chemical Name:
1H-Pyrazole-5-carboxamide, 4-amino-1-[3-chloro-4-(2-pyridinylmethoxy)phenyl]-3-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-
Synonyms
EGFR-IN-39;1H-Pyrazole-5-carboxamide, 4-amino-1-[3-chloro-4-(2-pyridinylmethoxy)phenyl]-3-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-
CBNumber:
CB012779765
Molecular Formula:
C24H25ClN6O3
Molecular Weight:
480.95
MDL Number:
MOL File:
2711105-48-3.mol
Last updated:2025-04-17 18:22:24
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1H-Pyrazole-5-carboxamide, 4-amino-1-[3-chloro-4-(2-pyridinylmethoxy)phenyl]-3-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]- Properties

Boiling point 687.1±55.0 °C(Predicted)
Density 1.42±0.1 g/cm3(Predicted)
pka 15.00±0.50(Predicted)

1H-Pyrazole-5-carboxamide, 4-amino-1-[3-chloro-4-(2-pyridinylmethoxy)phenyl]-3-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]- Chemical Properties,Uses,Production

Uses

EGFR-IN-39 is a potent inhibitor of EGFR. EGFR-IN-39 is an anti-tumor agent with low toxic side effects. EGFR-IN-39 is an acrylamide derivative compound. Overexpression and mutation of the epidermal growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-39 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185348A1, compound 2)[1].

References

[1] Yihan Wang, et al. Substituted acrylamide derivatives and compositions thereof and their uses. Patent WO2021185348A1.

1H-Pyrazole-5-carboxamide, 4-amino-1-[3-chloro-4-(2-pyridinylmethoxy)phenyl]-3-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Pyrazole-5-carboxamide, 4-amino-1-[3-chloro-4-(2-pyridinylmethoxy)phenyl]-3-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]- Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19939 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 26071 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 58

View Lastest Price from 1H-Pyrazole-5-carboxamide, 4-amino-1-[3-chloro-4-(2-pyridinylmethoxy)phenyl]-3-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
EGFR-IN-39 pictures 2025-05-01 EGFR-IN-39
2711105-48-3
 US $1980.00-1520.00 / mg 10g TargetMol Chemicals Inc.
  • EGFR-IN-39 pictures
  • EGFR-IN-39
    2711105-48-3
  • US $1980.00-1520.00 / mg
  • TargetMol Chemicals Inc.
1H-Pyrazole-5-carboxamide, 4-amino-1-[3-chloro-4-(2-pyridinylmethoxy)phenyl]-3-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]- EGFR-IN-39 2711105-48-3