P-gb-IN-1
- CAS No.
- 2632874-49-6
- Chemical Name:
- P-gb-IN-1
- Synonyms
- P-gb-IN-1;N-(4-(5-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)furan-2-yl)phenyl)-4-methoxybenzamide;Benzamide, N-[4-[5-[(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)carbonyl]-2-furanyl]phenyl]-4-methoxy-
- CBNumber:
- CB013712006
- Molecular Formula:
- C30H28N2O6
- Molecular Weight:
- 512.55
- MDL Number:
- MOL File:
- 2632874-49-6.mol
P-gb-IN-1 Chemical Properties,Uses,Production
Uses
P-gb-IN-1 (compound Ⅲ-8), a 2,5-disubstituted furan derivative, is a highly effective, broadspectrum P-glycoprotein (P-gp) inhibitor. P-gb-IN-1 displayed the reversal activity by inhibiting P-gp efflux. P-gb-IN-1 has a potent affinity to P-gp by forming H-bond interactions with residues Asn 721 and Met 986. P-gb-IN-1 possesses broad-spectrum reversal activity and low toxicity in MCF-7/ADR cells[1].
References
[1] Zhikun Yang, et al. Discovery of 2,5-disubstituted furan derivatives featuring a benzamide motif for overcoming P-glycoprotein mediated multidrug resistance in MCF-7/ADR cell. Eur J Med Chem. 2023 Sep 5;257:115462. DOI:10.1016/j.ejmech.2023.115462
P-gb-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
P-gb-IN-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9125 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29257 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 6710 | 58 |
