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GPX4-IN-5

GPX4-IN-5 structure

CAS No.: 2922824-09-5

Chemical Name:: GPX4-IN-5

Synonyms: GPX4-IN-5;GPX4-IN-5, 10 mM in DMSO;Acetamide, 2-chloro-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(4-fluoro-3,5-dimethoxyphenyl)-;2-Chloro-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-N-(4-fluoro-3,5-dimethoxyphenyl)acetamide

CBNumber:: CB013831998

Molecular Formula:: C18H17ClFNO5

Molecular Weight:: 381.78

MDL Number:

MOL File:: 2922824-09-5.mol

Last updated:2025-11-10 14:44:25

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GPX4-IN-5 Properties

Boiling point	632.5±55.0 °C(predicted)
Density	1.362±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
solubility	DMF: 1 mg/ml DMSO: 1 mg/ml Ethanol: Slightly Soluble
pka	-4.45±0.20(predicted)
form	Solid
color	White to light brown

GPX4-IN-5 Chemical Properties,Uses,Production

Uses

GPX4-IN-5 (Compound C18) is a GPX4 covalent inhibitor with an IC50 value of 0.12 μM. GPX4-IN-5 (Compound C18) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) [1].

References

[1] Chen T, et al. Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2023 Jul 27;66(14):10036-10059. DOI:10.1021/acs.jmedchem.3c00967

GPX4-IN-5 Preparation Products And Raw materials

Raw materials

Preparation Products

GPX4-IN-5 Suppliers

Global( 14)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4768	55
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	8011	55
Shanghai Chaolan Chemical Technology Center	021-QQ：65489617 15618227136	Sales@ATKchemical.com	China	9125	58
Jinan Jiuli Biotechnology Co. , Ltd.	15865264761	486064515@qq.com	China	4809	58
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	59936	58
Wuhan Shanhai Zhihe Biotechnology Co., Ltd.	17771424646	shoubull@126.com	China	957	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24961	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11973	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
Tianjin Kailiqi Biotechnology Co., Ltd.	55
Shanghai Chaolan Chemical Technology Center	58
Jinan Jiuli Biotechnology Co. , Ltd.	58
Bide Pharmatech Ltd.	58
Wuhan Shanhai Zhihe Biotechnology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58

View Lastest Price from GPX4-IN-5 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-12-05	GPX4-IN-5 2922824-09-5	US $43.00-158.00 / mg		99.58%	10g	TargetMol Chemicals Inc.

GPX4-IN-5
2922824-09-5
US $43.00-158.00 / mg
99.58%
TargetMol Chemicals Inc.

GPX4-IN-5 Spectrum

GPX4-IN-5(2922824-09-5)¹HNMR

GPX4-IN-5 2-Chloro-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-N-(4-fluoro-3,5-dimethoxyphenyl)acetamide Acetamide, 2-chloro-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(4-fluoro-3,5-dimethoxyphenyl)- GPX4-IN-5, 10 mM in DMSO 2922824-09-5