Azide-PEG2-iodide

Description

A bifunctional cross-linker containing PEG2 with terminal azide and iodide groups. This molecule is hydrophilic and increases the water solubility of conjugates that contain it.

The azide fragment readily reacts in click chemistry reactions with various alkyne-substituted biomolecules, and for cyclooctyne compounds, the reaction runs without any toxic copper catalyzers.

The iodide is a good leaving group, so it participates in nucleophile substitution reactions and can interact with various C-, N-, O-, and S-nucleophiles readily and efficiently.