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LAPAQUISTAT
- CAS No.
- 189060-13-7
- Chemical Name:
- LAPAQUISTAT
- Synonyms
- TAK-475;CS-1400;LAPAQUISTAT;Lapaquistat Acetate;Lapaquistat Acetate (TAK-475);Lapaquistat and Lapaquistat Acetate;1-[[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic acid;2-[1-[2-[1-(3-Acetoxy-2,2-diMethylpropyl)-7-chloro-5(S)-(2,3-diMethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3(R)-yl]acetyl]piperidin-4-yl]acetic acid;4-Piperidineacetic acid, 1-[2-[(3R,5S)-1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-;2-(1-(2-((3R,5S)-1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepin-3-yl)acetyl)piperidin-4-yl)acetic acid
- CBNumber:
- CB01509119
- Molecular Formula:
- C33H41ClN2O9
- Molecular Weight:
- 645.14
- MDL Number:
- MOL File:
- 189060-13-7.mol
Last updated:2023-05-21 10:59:17
| Melting point | 194-196℃ |
|---|---|
| Boiling point | 826.4±65.0 °C(Predicted) |
| Density | 1.246±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 4.66±0.10(Predicted) |
| form | Solid |
| color | White |
| FDA UNII | IUH3AY74O3 |
LAPAQUISTAT price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2168 | TAK-475 ≥98% (HPLC) | 189060-13-7 | 5mg | $155 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2168 | TAK-475 ≥98% (HPLC) | 189060-13-7 | 25mg | $603 | 2024-03-01 | Buy |
| TRC | L175500 | LapaquistatAcetate | 189060-13-7 | 25mg | $10725 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0007318 | LAPAQUISTAT ACETATE 95.00% | 189060-13-7 | 25MG | $12370.05 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0007318 | LAPAQUISTAT ACETATE 95.00% | 189060-13-7 | 10MG | $7230.3 | 2021-12-16 | Buy |
LAPAQUISTAT Chemical Properties,Uses,Production
Uses
A novel squalene synthase inhibitor. Lapaquistat acetate decreased plasma cholesterol and triglyceride levels, by lowering lipoproteins containing apoB100. Treatment with Lapaquistat acetate increased collagen concentration and transformed coronary plaques into fibromuscular plaques. Lapaquistat acetate also suppressed the expression of matrix metalloproteinase-1 and plasminogen activator inhibitor-1 in the plaque and increased peripheral coenzyme Q10 levels.Antiarteriosclerotics.
LAPAQUISTAT Preparation Products And Raw materials
Raw materials
Preparation Products
LAPAQUISTAT Suppliers
Global( 29)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ZHIWE CHEMTECH CO LTD | 021-20221225 13917446399 | sales@zhiwe.net | China | 580 | 61 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Wulechem Co., Ltd. | 13761914825 | wulesian@wulechem.com | China | 304 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Nanjing NingFan Pharm-Tech CO. LTD. | 17368696818 | China | 1986 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 58 |
| Alfa Chemistry | 58 |
| J & K SCIENTIFIC LTD. | 76 |
| ZHIWE CHEMTECH CO LTD | 61 |
| LGM Pharma | 70 |
| Chemsky (shanghai) International Co.,Ltd | 60 |
| Wulechem Co., Ltd. | 58 |
| SPIRO PHARMA | 55 |
| Nanjing NingFan Pharm-Tech CO. LTD. | 58 |
189060-13-7(LAPAQUISTAT)Related Search:
LAPAQUISTAT
Lapaquistat and Lapaquistat Acetate
Lapaquistat Acetate
2-[1-[2-[1-(3-Acetoxy-2,2-diMethylpropyl)-7-chloro-5(S)-(2,3-diMethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3(R)-yl]acetyl]piperidin-4-yl]acetic acid
TAK-475
1-[[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic acid
CS-1400
Lapaquistat Acetate (TAK-475)
4-Piperidineacetic acid, 1-[2-[(3R,5S)-1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-
2-(1-(2-((3R,5S)-1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepin-3-yl)acetyl)piperidin-4-yl)acetic acid
189060-13-7
C33H41ClN2O9
Amines
Chiral Reagents
Heterocycles
Inhibitors
Intermediates & Fine Chemicals
Pharmaceuticals