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2'-Deoxyguanosine monohydrate

2'-Deoxyguanosine monohydrate structure

CAS No.: 312693-72-4

Chemical Name:: 2'-Deoxyguanosine monohydrate

Synonyms: DG;DEOXYGUANOSINE-2';5′-Nucleotides &A-2'-DEOXYGUANOSINE;2'-DEOXY-D-GUANOSINE;Adenosine Impurity 16;GUANINE DESOXYRIBOSIDE;2'-DEOXYGUANOSINE USP/EP/BP;2'-Deoxyguanosine monohydrate;2'-Deoxyguanosine monohydrate

CBNumber:: CB0209021

Molecular Formula:: C10H15N5O5

Molecular Weight:: 285.26

MDL Number:: MFCD00150760

MOL File:: 312693-72-4.mol

MSDS File:: SDS

Last updated:2023-09-20 16:43:00

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2'-Deoxyguanosine monohydrate Properties

Melting point	>300 °C (dec.)(lit.)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	NH₄OH 1 M: 50 mg/mL, clear to very faintly turbid, yellow to brown
form	powder
pka	pK1:2.5(+1) (25°C,μ=0.1)
color	White to Off-White
BRN	39814
InChI	InChI=1/C10H13N5O4/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6/h3-6,16-17H,1-2H2,(H3,11,13,14,18)/t4-,5+,6+/s3
InChIKey	LZSCQUCOIRGCEJ-FPKZOZHISA-N
SMILES	OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)C[C@@H]1O \|&1:2,4,17,r\|
FDA UNII	G9481N71RO

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264b-P270-P301+P312-P330-P403-P501c

Hazard Codes

Xn,T

Risk Statements

22-25

Safety Statements

WGK Germany

10-23

TSCA

Yes

HS Code

2934999090

NFPA 704

	0
2		0

2'-Deoxyguanosine monohydrate price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D0901	2′-Deoxyguanosine monohydrate powder, BioReagent, suitable for cell culture, 99-100%	312693-72-4	100mg	$148	2024-03-01	Buy
Sigma-Aldrich	D0901	2′-Deoxyguanosine monohydrate powder, BioReagent, suitable for cell culture, 99-100%	312693-72-4	1g	$905	2024-03-01	Buy
Alfa Aesar	J14304	2'-Deoxyguanosine monohydrate, synthetic, 98+% (dry basis), Affymetrix/USB	312693-72-4	10g	$721.65	2024-03-01	Buy
Alfa Aesar	J60741	2'-Deoxyguanosine monohydrate 98+%	312693-72-4	1g	$78.4	2023-06-20	Buy
Alfa Aesar	J60741	2'-Deoxyguanosine monohydrate 98+%	312693-72-4	5g	$155	2023-06-20	Buy

Product number	Packaging	Price	Buy
D0901	100mg	$148	Buy
D0901	1g	$905	Buy
J14304	10g	$721.65	Buy
J60741	1g	$78.4	Buy
J60741	5g	$155	Buy

2'-Deoxyguanosine monohydrate Chemical Properties,Uses,Production

Description

2''-Deoxyguanosine is a purine nucleoside with diverse biological activities. It inhibits the clonogenic growth of HL-60 and K562 leukemia cells (IC₅₀s = 80 and 100 μM, respectively). 2''-Deoxyguanosine inhibits the growth of MOLT-4 T cells and MGL-8 B cells by 99.8 and 68.3%, respectively, when used at a concentration of 50 μM. It increases the number of binucleated cells, a marker of inhibited cytokinesis, in A. sativum meristems. 2''-Deoxyguanosine (>1 μM) also induces relaxation of precontracted isolated bovine lingual artery.

Chemical Properties

White to Off-White Solid. Soluble in NH4OH 1 M: 50 mg/mL, clear to very faintly turbid.

Uses

2′-Deoxyguanosine monohydrate has been used in stromal cell purification. It has also been used for the quantification of whole cell dNTP (deoxyribonucleotide triphosphate).

Definition

ChEBI: 2'-Deoxyguanosine monohydrate is a purine 2'-deoxyribonucleoside having guanine as the nucleobase. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purines 2'-deoxy-D-ribonucleoside and a purine 2'-deoxyribonucleoside. It is functionally related to a guanosine.

Application

2′-Deoxyguanosine monohydrate has been used as a nucleoside supplement:
to study its effect on mitochondrial DNA copy number in deoxyguanosine kinase (dguok) mutant zebrafish,
in tissue culture medium for deoxyribonucleotide triphosphate (dNTP) synthesis,
in RPMI (Roswell Park Memorial Institute)-1640 medium to eliminate the endogenous thymocytes.

Biological Functions

lu et al. found that 2'-Deoxyguanosine (2-dG) is a key immune signaling molecule in plant–microbe interactions and that Arabidopsis VENOSA4 (VEN4) is essential for plant immunity. 2-dG is the immunoreactive component in ZhiNengCong (ZNC). This compound induced classical immune responses, including ROS production, allose accumulation and MPKs phosphorylation, and upregulated the expression of plant immunity-associated genes. In addition, 2-dG-induced plant immunity requires salicylic acid (SA) receptor NPR1 (but not SA), ethylene (ET) signaling, pattern-recognition receptors/coreceptors (PRRs/coreceptors) and the ATP receptor P2K1[1]. VEN4 was involved in 2-dG biosynthesis and could convert dGTP to 2-dG.

Biochem/physiol Actions

Deoxyguanosine (dG) is a purine nucleoside that upon sequential phosphorylation (kinases) forms deoxyguanosine triphosphate (dGTP) which is used by DNA polymerases and reverse transcriptases to synthesize DNA(s). Deoxyguanosine is the most electron-rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.

References

[1] Chongchong Lu . “Discovery of a novel nucleoside immune signaling molecule 2′-deoxyguanosine in microbes and plants.” Journal of Advanced Research 46 (2023): Pages 1-15.

2'-Deoxyguanosine monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

2'-Deoxyguanosine monohydrate Suppliers

Global( 181)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Ribio Biotech Co.,Ltd	010-62664360 +8613328773880	wucy@ribio.com.cn	China	117	58
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58
SHANGHAI NOVRIBO BIOTECH	17821030819	June.Liu@Desano.com	China	73	58
Zhengzhou Chemprize Biotech Co., Ltd.	+86-86-0371-56768238 +8615981919713	sales@chemprize.com	China	297	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Hangzhou Measure Life Technology Co., LTD	+8613343730176	2924244016@qq.com	China	83	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60

Supplier	Advantage
Beijing Ribio Biotech Co.,Ltd	58
Yunbio Tech Co.,Ltd.	58
SHANGHAI NOVRIBO BIOTECH	58
Zhengzhou Chemprize Biotech Co., Ltd.	58
Hebei Yanxi Chemical Co., Ltd.	58
Hangzhou Measure Life Technology Co., LTD	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60

View Lastest Price from 2'-Deoxyguanosine monohydrate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-07	2'-Deoxyguanosine monohydrate 312693-72-4	US $0.00 / kg	1kg	99%	1000KG	Hangzhou Measure Life Technology Co., LTD
2023-09-14	2'-deoxyguanosine 312693-72-4	US $220.00-10.00 / kgkg	1kgkg	0.99	100	Hebei Yanxi Chemical Co., Ltd.
2023-09-06	2'-deoxyguanosine 312693-72-4	US $0.00-0.00 / KG	1KG	99%	500000kg	Hebei Guanlang Biotechnology Co., Ltd.

2'-Deoxyguanosine monohydrate
312693-72-4
US $0.00 / kg
99%
Hangzhou Measure Life Technology Co., LTD

2'-deoxyguanosine
312693-72-4
US $220.00-10.00 / kgkg
0.99
Hebei Yanxi Chemical Co., Ltd.

2'-deoxyguanosine
312693-72-4
US $0.00-0.00 / KG
99%
Hebei Guanlang Biotechnology Co., Ltd.

2'-Deoxyguanosine monohydrate Spectrum

2'-Deoxyguanosine monohydrate(312693-72-4)¹HNMR

312693-72-4(2'-Deoxyguanosine monohydrate)Related Search:

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2'-DEOXY-D-GUANOSINE 9-(2'-DEOXY-BETA-D-RIBOFURANOSYL)GUANINE A-2'-DEOXYGUANOSINE GUANINE DESOXYRIBOSIDE DEOXYGUANOSINE-2' [1',2',3',4',5'-13C5]2'-deoxyguanosine Monohydrate [2',2''-2H2]2'-deoxyguanosine Monohydrate [3'-2H]2'-deoxyguanosine Monohydrate 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymeth yl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one hydrate 2-Deoxyguanosine Monohydrate extrapure, 99% 5′-Nucleotides & 2'-Deoxyguanosine Monohydrate(2'-dG ? H?O) Adenosine Impurity 16 2'-Deoxyguanosine-[15N5] monohydrate 2'-DEOXYGUANOSINE USP/EP/BP Adenosine Impurity 16（2’ Deoxyguanosine Monohydrate） Biochemical reagent 99% CAS 312693-72-4 2'-Deoxyguanosine monohydrate DG 2'-Deoxyguanosine monohydrate Guanosine, 2'-deoxy-, hydrate (1:1) 2'-DeoxyGuanosine Monohydrate(2'-dG H2O) 2'-deoxy-Guanosine hydrate (1:1) 2'-Deoxyguanosine monohydrate 312693-72-4 C10H13N5O4H20 C10H1315N5O4H2O Specialty Synthesis Oligonucleotide Synthesis Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs Nucleosides DNA / RNA Synthesis BioChemical Biochemicals and Reagents Bases & Related Reagents Carbohydrates & Derivatives Heterocycles Nucleotides