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ChemicalBook >> CAS DataBase List >>(R)-5-(2-Aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione

(R)-5-(2-Aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione

(R)-5-(2-Aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione Structure
(R)-5-(2-Aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione structure
CAS No.
760173-05-5
Chemical Name:
(R)-5-(2-Aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione
Synonyms
BIA 5-453;EtaMicastat;(R)-5-(2-Aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione;2H-Imidazole-2-thione, 5-(2-aminoethyl)-1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-
CBNumber:
CB02484710
Molecular Formula:
C14H15F2N3OS
Molecular Weight:
311.35
MDL Number:
MFCD16619338
MOL File:
760173-05-5.mol
MSDS File:
SDS
Last updated:2025-08-21 22:16:43
Product description Number Pack Size Price
ETAMICASTAT 95.00% INB0001475 5MG $502.19
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(R)-5-(2-Aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione Properties

Boiling point 435.3±55.0 °C(Predicted)
Density 1.44
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 11.73±0.70(Predicted)
form powder
color white to beige
FDA UNII 9X96V6DBU4
UNSPSC Code 12352200
NACRES NA.77

(R)-5-(2-Aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation INB0001475 ETAMICASTAT 95.00% 760173-05-5 5MG $502.19 2021-12-16 Buy
Product number Packaging Price Buy
INB0001475 5MG $502.19 Buy

(R)-5-(2-Aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione Chemical Properties,Uses,Production

Uses

Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM[1]. Etamicastat can be used in the research of cardiovascular diseases[2].

Biological Activity

Orally active, potent, reversible and peripherally selective dopamine-β-hydroxylase (DBH) inhibitor.
Etamicast at (BIA 5-453) is an orally active, potent, reversible and peripherally selective dopamine-β-hydroxylase (DBH) inhibitor th at reduces both systolic (SBP) and diastolic (DBP) blood pressure.

in vivo

Etamicastat (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels[1].
Etamicastat (50 mg/kg; a single oral administration) exhibits moderate oral bioavailability (64%), Cmax (4.9 nM), and terminal elimination half-lives (T1/2=3.7 h) in male Wistar rats[1].

Animal Model:NMRi mice[1]
Dosage:100 mg/kg
Administration:Administered intraperitoneally
Result:Led to a significant reduction of noradrenaline levels (36% control) in heart with concomitant increasing in dopamine levels (850% of control).
Animal Model:Male Wistar rats[1]
Dosage:50 mg/kg (Pharmacokinetic Analysis)
Administration:Orally administered with at a dose volume of 10 mL/kg
Result:Oral bioavailability (64%), Cmax (4.9 nM), and (T1/2=3.7 h).

References

[1] Loureiro AI, et al. Etamicastat, a new dopamine-?-hydroxylase inhibitor, pharmacodynamics and metabolism in rat. Eur J Pharmacol. 2014 Oct 5;740:285-94. DOI:10.1016/j.ejphar.2014.07.027
[2] ManuelVaz-da-Silva, et al. Cardiac safety profile of etamicastat, a novel peripheral selective dopamine-β-hydroxylase inhibitor in non-human primates, human young and elderly healthy volunteers and hypertensive patients. IJC Metabolic & Endocrine. 2015 Ju

(R)-5-(2-Aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-5-(2-Aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39035 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19962 58
BOC Sciences -- info@bocsci.com USA 0 65
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29641 58
Merck KGaA 21-20338288 ordercn@merckgroup.com China 6394 58
Adooq Bioscience LLC 400-025-6535 sales@adooq.cn China 6215 58
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
BOC Sciences 65
TargetMol Chemicals Inc. 58
Merck KGaA 58
Adooq Bioscience LLC 58

View Lastest Price from (R)-5-(2-Aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Etamicastat pictures 2025-08-21 Etamicastat
760173-05-5
 US $2420.00-3180.00 / mg 10g TargetMol Chemicals Inc.
Etamicastat pictures 2025-07-18 Etamicastat
760173-05-5
 US $2420.00-3180.00 / mg 10g TargetMol Chemicals Inc.
  • Etamicastat pictures
  • Etamicastat
    760173-05-5
  • US $2420.00-3180.00 / mg
  • TargetMol Chemicals Inc.
  • Etamicastat pictures
  • Etamicastat
    760173-05-5
  • US $2420.00-3180.00 / mg
  • TargetMol Chemicals Inc.
(R)-5-(2-Aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione EtaMicastat BIA 5-453 2H-Imidazole-2-thione, 5-(2-aminoethyl)-1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro- 760173-05-5 C14H15F2N3OS