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Methyl 2-(Boc-amino)isonicotinate

CAS No.
639091-75-1
Chemical Name:
Methyl 2-(Boc-amino)isonicotinate
Synonyms
Methyl 2-(Boc-amino)isonicotinate;2-Boc-amino-isonicotinic acid methyl ester;Methyl 2-((tert-butoxycarbonyl)aMino)isonicotinate;2-tert-Butoxycarbonylamino-isonicotinic acid methyl ester;methyl 2-(tert-butoxycarbonylamino)pyridine-4-carboxylate;Methyl 2-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-4-carboxylate;2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-pyridinecarboxylic acidmethylester;4-Pyridinecarboxylic acid, 2-[[(1,1-diMethylethoxy)carbonyl]aMino]-, Methyl ester
CBNumber:
CB02499400
Molecular Formula:
C12H16N2O4
Molecular Weight:
252.27
MDL Number:
MFCD11504796
MOL File:
639091-75-1.mol
MSDS File:
SDS
Last updated:2023-07-10 08:28:02

Methyl 2-(Boc-amino)isonicotinate Properties

Melting point 75.1~75.2℃
Boiling point 325.5±27.0 °C(Predicted)
Density 1.203±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 12.12±0.70(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330
HS Code  2922390090

Methyl 2-(Boc-amino)isonicotinate price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC M295635 Methyl2-(Boc-amino)isonicotinate 639091-75-1 250mg $55 2021-12-16 Buy
Matrix Scientific 018214 2-(2,2-Dimethyl-propionylamino)-isonicotinic acidmethyl ester 639091-75-1 500mg $116 2021-12-16 Buy
Matrix Scientific 118101 Methyl 2-((tert-butoxycarbonyl)amino)isonicotinate 639091-75-1 5g $301 2021-12-16 Buy
SynQuest Laboratories 4H58-1-8C Methyl 2-((tert-butoxycarbonyl)amino)isonicotinate 639091-75-1 5G $356 2021-12-16 Buy
AK Scientific Y6341 Methyl2-(tert-butoxycarbonylamino)isonicotinate 639091-75-1 10g $370 2021-12-16 Buy
Product number Packaging Price Buy
M295635 250mg $55 Buy
018214 500mg $116 Buy
118101 5g $301 Buy
4H58-1-8C 5G $356 Buy
Y6341 10g $370 Buy

Methyl 2-(Boc-amino)isonicotinate Chemical Properties,Uses,Production

Synthesis

A 500 mL round bottomed flask was charged with methyl 2-aminoisonicotinate (5.0 g, 32.9 mmol) and suspended in t-BuOH (200 mL). To this stirring solution was added di-tert-butyl dicarbonate (7.53 g, 34.5 mmol). The flask was vented and placed in an oil bath preheated to 50°C. The reaction mixture was let stir overnight. After 22 hours LCMS showed near complete conversion of starting material. The mixture was cooled to room temperature and filtered. The material was taken on without any further purification. Yield 5.93 g of white solid, Methyl 2-(Boc-amino)isonicotinate.  1H NMR (400 MHz, DMSO-d6) δ ppm 10.14 (1H, s), 8.43 (1H, dd, J=5.02, 0.75 Hz), 8.33 (1H, s), 7.45 (1H, dd, J=5.02, 1.51 Hz), 3.89 (3H, s), 1.48 (9H, s).
synthesis of Methyl 2-(Boc-amino)isonicotinate

6937-03-7
24424-99-5
639091-75-1
Synthesis of Methyl 2-(Boc-amino)isonicotinate from Methyl 2-aminopyridine-4-carboxylate and Di-tert-butyl dicarbonate

Methyl 2-(Boc-amino)isonicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 sales@capotchem.com China 18217 66
2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-pyridinecarboxylic acidmethylester Methyl 2-(Boc-amino)isonicotinate 4-Pyridinecarboxylic acid, 2-[[(1,1-diMethylethoxy)carbonyl]aMino]-, Methyl ester Methyl 2-((tert-butoxycarbonyl)aMino)isonicotinate 2-Boc-amino-isonicotinic acid methyl ester 2-tert-Butoxycarbonylamino-isonicotinic acid methyl ester Methyl 2-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-4-carboxylate methyl 2-(tert-butoxycarbonylamino)pyridine-4-carboxylate 639091-75-1