EX527
- CAS No.
- 848193-68-0
- Chemical Name:
- EX527
- Synonyms
- EX527;CS-573;EX-527(S);(±)-EX-527;(S)-Selisistat;EX-527 (S-enantioMer);Selisistat S-enantiomer;Selisistat S-enantiomer, 10 mM in DMSO;Selisistat S-enantiomer(EX-527 S-enantiomer);(1S)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
- CBNumber:
- CB02507286
- Molecular Formula:
- C13H13ClN2O
- Molecular Weight:
- 248.71
- MDL Number:
- MFCD20503073
- MOL File:
- 848193-68-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| EX 527 ≥98%(HPLC) | 2780 | 10 | $223 |
| EX 527 | 366881 | 10mg | $296 |
| EX 527 | 255275 | 1mg | $333 |
| SelisistatS-enantiomer 98.50% | CS-3574 | 5mg | $420 |
| EX 527 >98% | orb545819 | 25mg | $521.9 |
| Boiling point | 531.7±38.0 °C(Predicted) |
|---|---|
| Density | 1.388 |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 16.12±0.40(Predicted) |
| form | Powder |
| color | Light yellow to yellow |
| FDA UNII | MUD9R3TJV3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H317 |
| Precautionary statements | P280-P305+P351+P338 |
EX527 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 2780 | EX 527 ≥98%(HPLC) | 848193-68-0 | 10 | $223 | 2021-12-16 | Buy |
| Usbiological | 366881 | EX 527 | 848193-68-0 | 10mg | $296 | 2021-12-16 | Buy |
| Usbiological | 255275 | EX 527 | 848193-68-0 | 1mg | $333 | 2021-12-16 | Buy |
| ChemScene | CS-3574 | SelisistatS-enantiomer 98.50% | 848193-68-0 | 5mg | $420 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545819 | EX 527 >98% | 848193-68-0 | 25mg | $521.9 | 2021-12-16 | Buy |
EX527 Chemical Properties,Uses,Production
Uses
(S)-Selisistat ((S)-EX-527) is a potent and selective SIRT1 inhibitor, with an IC50 of 98 nM.
Definition
ChEBI: (S)-selisistat is a 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide that has S configuration It is the active enantiomer. It has a role as a Sir1 inhibitor. It is an enantiomer of a (R)-selisistat.
in vivo
(S)-Selisistat abolishes Resveratrol (RSV)-induced attenuation of microvascular inflammation in ob/ob septic mice. Finally, ob/ob mice in Sepsis+RSV group has significantly increased 7-day survival vs. Sepsis+Vehicle group[3].
IC 50
SIRT1: 98 nM (IC50)
References
[1] Solomon JM, et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006 Jan;26(1):28-38. DOI:10.1128/MCB.26.1.28-38.2006
[2] Jia Y, et al. SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells. PLoS One. 2015 Mar 20;10(3):e0120849. DOI:10.1371/journal.pone.0120849
[3] Wang X, et al. Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice. Obesity (Silver Spring). 2015 Jun;23(6):1209-17. DOI:10.1002/oby.21086
[4] Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54. DOI:10.1021/jm050522v
EX527 Preparation Products And Raw materials
Raw materials
Preparation Products
EX527 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 18971495150; | sales@sun-shinechem.com | China | 1150 | 64 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| Credit Asia Chemical Co., Ltd. | +86 (21) 61124340 | China | 9756 | 58 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89689 | 60 |
| Amatek Scientific Co. Ltd. | 0512-56316828 | info@amateksci.com | China | 28769 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4660 | 60 |
View Lastest Price from EX527 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-21 | Selisistat S-enantiomer
848193-68-0
|
US $153.00-349.00 / mg | 99.86% | 10g | TargetMol Chemicals Inc. |
-
- Selisistat S-enantiomer
848193-68-0
- US $153.00-349.00 / mg
- 99.86%
- TargetMol Chemicals Inc.
